Recent advances in single-cell sequencing technologies offer an opportunity to explore cell–
cell communication in tissues systematically and with reduced bias. A key challenge is …

Multicellular organisms are composed of diverse cell types that must coordinate their
behaviors through communication. Cell–cell communication (CCC) is essential for growth …

No cell lives in a vacuum, and the molecular interactions between cells define most
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …

The human vascular system, comprising endothelial (EC) and mural cells, covers a vast
surface area in the body, providing a critical interface between blood and tissue …

Clonal hematopoiesis (CH) increases inflammasome-linked atherosclerosis, but the
mechanisms by which CH mutant cells transmit inflammatory signals to nonmutant cells are …

Current rheumatoid arthritis (RA) treatments do not restore immune tolerance. Investigating
dendritic cell (DC) populations in human synovial tissue (ST) may reveal pathways to …

From the catalytic breakdown of nutrients to signaling, interactions between metabolites and
proteins play an essential role in cellular function. An important case is cell–cell …

Background & Aims The pathophysiology of Crohn's-like disease of the pouch (CDP) in
patients with a history of ulcerative colitis (UC) is unknown. We examined mucosal cells from …

Classic Hodgkin Lymphoma (cHL) is a tumor composed of rare malignant Hodgkin and
Reed-Sternberg (HRS) cells nested within a T-cell rich inflammatory immune infiltrate. cHL is …

Abstract Introduction In Crohn's disease (CD), lesions are mainly distributed in a segmental
manner, with the primary sites of involvement being the ileum and colon. Heterogeneity in …