Role of O-linked N-acetylglucosamine protein modification in cellular (patho)physiology
In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
Analytical and biochemical perspectives of protein O-GlcNAcylation
Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …
unique monosaccharide modification discovered in the early 1980s. With the technological …
Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance
Q Shi, Q Shen, Y Liu, Y Shi, W Huang, X Wang, Z Li… - Cancer cell, 2022 - cell.com
How glucose metabolism remodels pro-tumor functions of tumor-associated macrophages
(TAMs) needs further investigation. Here we show that M2-like TAMs bear the highest …
(TAMs) needs further investigation. Here we show that M2-like TAMs bear the highest …
O-GlcNAc transferase promotes influenza A virus–induced cytokine storm by targeting interferon regulatory factor–5
In this study, we demonstrated an essential function of the hexosamine biosynthesis
pathway (HBP)–associated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling in …
pathway (HBP)–associated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling in …
O-GlcNAcylation and its role in the immune system
YH Chang, CL Weng, KI Lin - Journal of biomedical science, 2020 - Springer
Abstract O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a type of glycosylation that
occurs when a monosaccharide, O-GlcNAc, is added onto serine or threonine residues of …
occurs when a monosaccharide, O-GlcNAc, is added onto serine or threonine residues of …
O-GlcNAc transferase suppresses inflammation and necroptosis by targeting receptor-interacting serine/threonine-protein kinase 3
X Li, W Gong, H Wang, T Li, KS Attri, RE Lewis… - Immunity, 2019 - cell.com
Elevated glucose metabolism in immune cells represents a hallmark feature of many
inflammatory diseases, such as sepsis. However, the role of individual glucose metabolic …
inflammatory diseases, such as sepsis. However, the role of individual glucose metabolic …
Integration of O-GlcNAc into stress response pathways
KMM Fahie, KN Papanicolaou, NE Zachara - Cells, 2022 - mdpi.com
The modification of nuclear, mitochondrial, and cytosolic proteins by O-linked βN-
acetylglucosamine (O-GlcNAc) has emerged as a dynamic and essential post-translational …
acetylglucosamine (O-GlcNAc) has emerged as a dynamic and essential post-translational …
O-GlcNAc transferase links glucose metabolism to MAVS-mediated antiviral innate immunity
Increased glucose metabolism in immune cells not only serves as a hallmark feature of
acute inflammation but also profoundly affects disease outcome following bacterial infection …
acute inflammation but also profoundly affects disease outcome following bacterial infection …
Listeria monocytogenes upregulates mitochondrial calcium signalling to inhibit LC3-associated phagocytosis as a survival strategy
T Li, L Kong, X Li, S Wu, KS Attri, Y Li, W Gong… - Nature …, 2021 - nature.com
Mitochondria are believed to have originated~ 2.5 billion years ago. As well as energy
generation in cells, mitochondria have a role in defence against bacterial pathogens …
generation in cells, mitochondria have a role in defence against bacterial pathogens …
Mechanistic roles for altered O-GlcNAcylation in neurodegenerative disorders
Neurodegenerative diseases such as Alzheimer's and Parkinson's remain highly prevalent
and incurable disorders. A major challenge in fully understanding and combating the …
and incurable disorders. A major challenge in fully understanding and combating the …