This Review examines parts per million (ppm) palladium concentrations in catalytic cross-
coupling reactions and their relationship with mole percentage (mol%). Most studies in …

The catalytic and enantioselective construction of quaternary (all-carbon substituents)
stereocenters poses a formidable challenge in organic synthesis due to the hindrance …

Catalytic cross-coupling by transition metals has revolutionized the formation of carbon–
carbon bonds in organic synthesis. However, the challenge of forming multiple alkyl–alkyl …

Metallaphotoredox cross-coupling is a well-established strategy for generating clinically
privileged aliphatic scaffolds via single-electron reactivity. Correspondingly, expanding …

Selective construction of two distinct alkyl–alkyl bonds across the C= C bond of simple
unactivated olefins is a persistent challenge in organic synthesis. Transition metal-catalysed …

Given the widespread significance of vicinal diamine units in organic synthesis,
pharmaceuticals and functional materials, as well as in privileged molecular catalysts, an …

Diradical generation followed by radical–radical cross-coupling is a powerful synthetic tool,
but its detailed mechanism has yet to be established. Herein, we proposed and confirmed a …

Iron-catalyzed cross-coupling reactions are difficult to achieve because they usually require
a highly reactive, low-valent iron catalyst to undergo the oxidative addition process. Here …

Bicyclo [1.1. 1] pentanes (BCPs) are of great interest to the agrochemical, materials, and
pharmaceutical industries. In particular, synthetic methods to access 1, 3-dicarbosubsituted …

Cross-electrophile couplings are influential reactions that typically require a terminal
reductant or photoredox conditions. We discovered an iron-catalyzed reaction that couples …