Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …
Redox regulation of the immune response
G Morris, M Gevezova, V Sarafian… - Cellular & Molecular …, 2022 - nature.com
The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …
Akt signaling pathway in macrophage activation and M1/M2 polarization
E Vergadi, E Ieronymaki, K Lyroni… - The Journal of …, 2017 - journals.aai.org
Macrophages become activated initiating innate immune responses. Depending on the
signals, macrophages obtain an array of activation phenotypes, described by the broad …
signals, macrophages obtain an array of activation phenotypes, described by the broad …
Induction of interleukin-10 producing dendritic cells as a tool to suppress allergen-specific T helper 2 responses
S Schülke - Frontiers in immunology, 2018 - frontiersin.org
Dendritic cells (DCs) are gatekeepers of the immune system that control induction and
polarization of primary, antigen-specific immune responses. Depending on their …
polarization of primary, antigen-specific immune responses. Depending on their …
mTOR signaling in disease
E Dazert, MN Hall - Current opinion in cell biology, 2011 - Elsevier
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central
controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in …
controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in …
The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism
JD Powell, GM Delgoffe - Immunity, 2010 - cell.com
In the two-signal model of T cell activation, the outcome of antigen recognition is determined
by the integration of multiple cues in the immune microenvironment. mTOR is an …
by the integration of multiple cues in the immune microenvironment. mTOR is an …
Metabolic shifts in immunity and inflammation
DJ Kominsky, EL Campbell… - The Journal of Immunology, 2010 - journals.aai.org
Sites of ongoing inflammation and triggered immune responses are characterized by
significant changes in metabolic activity. Recent studies have indicated that such shifts in …
significant changes in metabolic activity. Recent studies have indicated that such shifts in …
Fighting the SARS-CoV-2 pandemic requires a global approach to understanding the heterogeneity of vaccine responses
Host genetic and environmental factors including age, biological sex, diet, geographical
location, microbiome composition and metabolites converge to influence innate and …
location, microbiome composition and metabolites converge to influence innate and …
Dietary leucine-an environmental modifier of insulin resistance acting on multiple levels of metabolism
Environmental factors, such as the macronutrient composition of the diet, can have a
profound impact on risk of diabetes and metabolic syndrome. In the present study we …
profound impact on risk of diabetes and metabolic syndrome. In the present study we …
Immunoregulation with mTOR inhibitors to prevent COVID‐19 severity: A novel intervention strategy beyond vaccines and specific antiviral medicines
Y Zheng, R Li, S Liu - Journal of medical virology, 2020 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) has become a major global public health
concern. The mortality rate for critically ill patients is up to 60%, and, thus, reducing the …
concern. The mortality rate for critically ill patients is up to 60%, and, thus, reducing the …