Intrinsic factors behind long‐COVID: II. SARS‐CoV‐2, extracellular vesicles, and neurological disorders

YA El‐Maradny, A Rubio‐Casillas… - Journal of Cellular …, 2023 - Wiley Online Library
With the decline in the number of new Severe Acute Respiratory Syndrome Coronavirus 2
(SARS‐CoV‐2) infections, the World Health Organization announced the end of the SARS …

Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions

A Shafqat, MC Masters, U Tripathi, T Tchkonia… - Ageing Research …, 2024 - Elsevier
It has been four years since long COVID—the protracted consequences that survivors of
COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life …

Differentiation of prior SARS-CoV-2 infection and postacute sequelae by standard clinical laboratory measurements in the RECOVER cohort

KM Erlandson, LN Geng, CA Selvaggi… - Annals of internal …, 2024 - acpjournals.org
Background: There are currently no validated clinical biomarkers of postacute sequelae of
SARS-CoV-2 infection (PASC). Objective: To investigate clinical laboratory markers of SARS …

Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in long COVID

HK Al-Hakeim, A Khairi Abed… - Frontiers in Molecular …, 2023 - frontiersin.org
Critical COVID-19 disease is accompanied by depletion of plasma tryptophan (TRY) and
increases in indoleamine-dioxygenase (IDO)-stimulated production of neuroactive …

Increased insulin resistance due to Long COVID is associated with depressive symptoms and partly predicted by the inflammatory response during acute infection

HK Al-Hakeim, HT Al-Rubaye, AS Jubran… - Brazilian Journal of …, 2023 - SciELO Brasil
Objective: Some months after the remission of acute COVID-19, some individuals show
depressive symptoms, which are predicted by increased peak body temperature (PBT) and …

Serum ferritin level during hospitalization is associated with Brain Fog after COVID-19

T Ishikura, T Nakano, T Kitano, T Tokuda… - Scientific Reports, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) remains an epidemic worldwide. Most
patients suffer residual symptoms, the so-called “Long COVID,” which includes respiratory …

Molecular mimicry between SARS-CoV-2 proteins and human self-antigens related with autoimmune Central Nervous System (CNS) disorders

EG Gutman, RA Fernandes, JV Raposo-Vedovi… - Microorganisms, 2023 - mdpi.com
SARS-CoV-2 can trigger autoimmune central nervous system (CNS) diseases in genetically
susceptible individuals, a mechanism poorly understood. Molecular mimicry (MM) has been …

[HTML][HTML] Brain-targeted autoimmunity is strongly associated with long COVID and its chronic fatigue syndrome as well as its affective symptoms

AF Almulla, M Maes, B Zhou, HK Al-Hakeim… - Journal of Advanced …, 2024 - Elsevier
Introduction Autoimmune responses contribute to the pathophysiology of Long COVID,
affective symptoms and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) …

From human herpes virus‐6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue …

M Maes, AF Almulla, X Tang… - Journal of medical …, 2024 - Wiley Online Library
Inflammation and autoimmune responses contribute to the pathophysiology of Long COVID,
and its affective and chronic fatigue syndrome symptoms, labeled “the physio‐affective …

Reactivation of herpesvirus type 6 and IgA/IgM-mediated responses to activin-A underpin long COVID, including affective symptoms and chronic fatigue syndrome

A Vojdani, AF Almulla, B Zhou, HK Al-Hakeim… - Acta …, 2024 - cambridge.org
Background: Persistent infection with severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), reactivation of dormant viruses, and immune-oxidative responses are …