Major strides have been made in the development of FLASH radiotherapy (FLASH RT) in
the last ten years, but there are still many obstacles to overcome for transfer to the clinic to …

Radiotherapy is an important treatment for many unresectable advanced malignant tumors,
and radiotherapy-associated inflammatory reactions to radiation and other toxic side effects …

FLASH radiotherapy holds promise for treating solid tumors given the potential lower toxicity
in normal tissues but its therapeutic effects on tumor immunity remain largely unknown …

Purpose. The sparing effect of ultra-high dose rate (FLASH) radiotherapy has been reported,
but its potential to mitigate depletion of circulating blood and lymphocytes (CL) has not been …

Purpose The understanding of how varying radiation beam parameter settings affect the
induction and magnitude of the FLASH effect remains limited. We sought to systematically …

Stereotactic body radiation therapy (SBRT) has emerged as a standard treatment approach
for early-stage lung cancer and intrathoracic oligometastatic or oligoprogressive disease …

The current monochromatic beam mode (ie, uHDR irradiation mode) of the scanned carbon-
ion beam lacks a dedicated dose monitor, making the beam control challenging. We …

The “FLASH effect” is an increased therapeutic index, that is, reduced normal tissue toxicity
for a given degree of anti-cancer efficacy, produced by ultra-rapid irradiation delivered on …

Abstract FLASH radiotherapy (FLASH-RT) has great potential to improve patient outcomes. It
delivers radiation doses at an ultra-high dose rate (UHDR:≥ 40 Gy/s) in a single instant or a …

Background/Aim: Pre-clinical studies have shown that irradiation with electrons at an ultra-
high dose-rate (FLASH) spares normal tissue while maintaining tumor control. However …