Placenta: an old organ with new functions

S Khorami-Sarvestani, N Vanaki, S Shojaeian… - Frontiers in …, 2024 - frontiersin.org
The transition from oviparity to viviparity and the establishment of feto-maternal
communications introduced the placenta as the major anatomical site to provide nutrients …

Placental adaptation: what can we learn from birthweight: placental weight ratio?

CE Hayward, S Lean, CP Sibley, RL Jones… - Frontiers in …, 2016 - frontiersin.org
Appropriate fetal growth relies upon adequate placental nutrient transfer. Birthweight:
placental weight ratio (BW: PW ratio) is often used as a proxy for placental efficiency, defined …

Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction

A Colson, P Sonveaux, F Debiève… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction

H Yung, S Calabrese, D Hynx, BA Hemmings… - The American journal of …, 2008 - Elsevier
Unexplained intrauterine growth restriction of the fetus (IUGR) results from impaired
placental development, frequently associated with maternal malperfusion. Some cases are …

[PDF][PDF] The influence of the intrauterine environment on human placental development

GJ Burton, E Jauniaux… - International Journal of …, 2010 - researchgate.net
Development of the human placenta is modulated heavily by the intrauterine environment.
During the first trimester, development takes place in a low oxygen environment supported …

Pre-pregnancy body mass index, gestational weight gain, and other maternal characteristics in relation to infant birth weight

IO Frederick, MA Williams, AE Sales, DP Martin… - Maternal and child …, 2008 - Springer
Objectives Infant birth weight is influenced by modifiable maternal pre-pregnancy behaviors
and characteristics. We evaluated the relationship among pre-pregnancy body mass index …

Regulators involved in trophoblast syncytialization in the placenta of intrauterine growth restriction

H Zhou, C Zhao, P Wang, W Yang, H Zhu… - Frontiers in …, 2023 - frontiersin.org
Placental dysfunction refers to the insufficiency of placental perfusion and chronic hypoxia
during early pregnancy, which impairs placental function and causes inadequate supply of …

The thrifty phenotype as an adaptive maternal effect

JCK Wells - Biological Reviews, 2007 - Wiley Online Library
Human diseases in adulthood are increasingly associated with growth patterns in early life,
implicating early‐life nutrition as the underlying mechanism. The thrifty phenotype …

The placenta and intrauterine programming

AL Fowden, AJ Forhead, PM Coan… - Journal of …, 2008 - Wiley Online Library
Intrauterine programming is the process by which the structure and function of tissues are
altered permanently by insults acting during early development. In mammals, the placenta …

Praegnatio perturbatio—impact of endocrine-disrupting chemicals

V Padmanabhan, W Song… - Endocrine reviews, 2021 - academic.oup.com
The burden of adverse pregnancy outcomes such as preterm birth and low birth weight is
considerable across the world. Several risk factors for adverse pregnancy outcomes have …