Antibodies targeting programmed cell death protein-1 (PD-1) or its ligand PD-L1 rescue T
cells from exhausted status and revive immune response against cancer cells. Based on the …

Adjuvants are indispensable components of vaccines. Despite being widely used in
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …

Bioactive materials are a special class of biomaterials that can react in vivo to induce a
biological response or regulate biological functions, thus achieving a better curative effect …

Nutritional metal ions play critical roles in many important immune processes. Hence, the
effective modulation of metal ions may open up new forms of immunotherapy, termed as …

The immunologically “cold” microenvironment of triple negative breast cancer results in
resistance to current immunotherapy. Here, we reveal the immunoadjuvant property of gas …

The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

As an essential micronutrient, manganese (Mn) participates in various physiological
processes and plays important roles in host immune system, hematopoiesis, endocrine …

CD8+ T cell-mediated cancer clearance is often suppressed by the interaction between
inhibitory molecules like PD-1 and PD-L1, an interaction acts like brakes to prevent T cell …

The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …

Both T-cell deprivation and insufficient tumor immunogenicity seriously hinder the efficacy of
immune-mediated tumor destruction in melanoma. In this work, an amphiphilic polyethylene …