Adjuvants are indispensable components of vaccines. Despite being widely used in
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …

Antibodies targeting programmed cell death protein-1 (PD-1) or its ligand PD-L1 rescue T
cells from exhausted status and revive immune response against cancer cells. Based on the …

The immunologically “cold” microenvironment of triple negative breast cancer results in
resistance to current immunotherapy. Here, we reveal the immunoadjuvant property of gas …

As an essential micronutrient, manganese (Mn) participates in various physiological
processes and plays important roles in host immune system, hematopoiesis, endocrine …

Oncolytic bacteria can trigger innate immune activity. However, the antitumour efficacy of
inactivated bacteria is poor, and attenuated live bacteria pose substantial safety risks. Here …

Bioactive materials are a special class of biomaterials that can react in vivo to induce a
biological response or regulate biological functions, thus achieving a better curative effect …

Nutritional metal ions play critical roles in many important immune processes. Hence, the
effective modulation of metal ions may open up new forms of immunotherapy, termed as …

Abstract cGAS-STING pathway is a key DNA-sensing machinery and emerges as a
promising target to overcome the immunoresistance of solid tumors. Here we describe a …

Insufficient activation of the stimulator of interferon genes (STING) signaling pathway and
profoundly immunosuppressive microenvironment largely limits the effect of cancer …

Both T-cell deprivation and insufficient tumor immunogenicity seriously hinder the efficacy of
immune-mediated tumor destruction in melanoma. In this work, an amphiphilic polyethylene …