Background Preclinical data suggest that general anaesthetics affect brain development.
There is mixed evidence from cohort studies that young children exposed to anaesthesia …

Background Neonates and infants requiring anaesthesia are at risk of physiological
instability and complications, but triggers for peri-anaesthetic interventions and associations …

Background Exposure of young animals to general anesthesia (GA) causes
neurodegeneration and lasting behavioral abnormalities; whether these findings translate to …

General anesthesia has been unequivocally linked to abnormal development of the central
nervous system, leading to neurocognitive impairments in laboratory models. In vitro and in …

BACKGROUND: Anesthetics induce widespread cell death, permanent neuronal deletion,
and neurocognitive impairment in immature animals, raising substantial concerns about …

The purpose of this trial was to examine isoflurane exposure in children utilizing the
nonhuman primate (NHP) model. This translational research is important because there is …

Background Retrospective studies in humans have shown a higher prevalence of learning
disabilities in children that received multiple exposures to general anesthesia before the age …

Background: Animal studies demonstrate general anesthetic (GA) toxicity in the develo**
brain. Clinical reports raise concern, but the risk of GA exposure to neurodevelopment in …