Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

Blood vessels form a versatile transport network that is best known for its critical roles in
processes such as tissue oxygenation, metabolism and immune surveillance. The …

Abnormal subchondral bone remodeling featured by overactivated osteoclastogenesis
leads to articular cartilage degeneration and osteoarthritis (OA) progression, but the …

Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects
in articular cartilage can induce debilitating degenerative joint diseases such as …

Osteoarthritis (OA) is a common disease that endangers millions of middle‐aged and elderly
people worldwide. Researchers from different fields have made great efforts and achieved …

Background: Knee osteoarthritis (KOA) is one of the most common chronic musculoskeletal
disorders worldwide, for which exosomes derived from stem cells may provide an effective …

Abstract Prostaglandin E2 (PGE2), a major cyclooxygenase-2 (COX-2) product, is highly
secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis (OA) …

The interoception maintains proper physiological conditions and metabolic homeostasis by
releasing regulatory signals after perceving changes in the internal state of the organism …

The mechanisms that coordinate the shift from joint homeostasis to osteoarthritis (OA)
remain unknown. No pharmacological intervention can currently prevent the progression of …

Since the progression of osteoarthritis (OA) is closely associated with synovitis and cartilage
destruction, the inhibition of inflammatory responses in synovial macrophages and reactive …