Histone deacetylases (HDACs): characterization of the classical HDAC family
Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly
influenced by the post-translational modification of histones, the building blocks of …
influenced by the post-translational modification of histones, the building blocks of …
Transcription factor Bhlhe40 in immunity and autoimmunity
The basic helix-loop-helix transcription factor (TF) Bhlhe40 is emerging as a key regulator of
immunity during infection, autoimmunity, and inflammatory conditions. We describe the roles …
immunity during infection, autoimmunity, and inflammatory conditions. We describe the roles …
Characterization of peripheral circadian clocks in adipose tissues
First described in the suprachiasmatic nucleus, circadian clocks have since been found in
several peripheral tissues. Although obesity has been associated with dysregulated …
several peripheral tissues. Although obesity has been associated with dysregulated …
Delta–Notch—and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors
Hes and Hey genes are the mammalian counterparts of the Hairy and Enhancer-of-split type
of genes in Drosophila and they represent the primary targets of the Delta–Notch signaling …
of genes in Drosophila and they represent the primary targets of the Delta–Notch signaling …
Suppression of PGC-1α is critical for reprogramming oxidative metabolism in renal cell carcinoma
Long believed to be a byproduct of malignant transformation, reprogramming of cellular
metabolism is now recognized as a driving force in tumorigenesis. In clear cell renal cell …
metabolism is now recognized as a driving force in tumorigenesis. In clear cell renal cell …
Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning
RL Davis, DL Turner - Oncogene, 2001 - nature.com
The basic-helix-loop-helix (bHLH) proteins are a superfamily of DNA-binding transcription
factors that regulate numerous biological processes in both invertebrates and vertebrates …
factors that regulate numerous biological processes in both invertebrates and vertebrates …
Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view
T Vanhaecke, P Papeleu, G Elaut… - Current medicinal …, 2004 - ingentaconnect.com
Modulation of chromatin structure through histone acetylation/deacetylation is known to be
one of the major mechanisms involved in the regulation of gene expression. Two opposing …
one of the major mechanisms involved in the regulation of gene expression. Two opposing …
Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection
The cytokine IL-10 antagonizes pathways that control Mycobacterium tuberculosis (Mtb)
infection. Nevertheless, the impact of IL-10 during Mtb infection has been difficult to decipher …
infection. Nevertheless, the impact of IL-10 during Mtb infection has been difficult to decipher …
Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self‐renewal and identity
R Rauschmeier, C Gustafsson, A Reinhardt… - The EMBO …, 2019 - embopress.org
Tissues in multicellular organisms are populated by resident macrophages, which perform
both generic and tissue‐specific functions. The latter are induced by signals from the …
both generic and tissue‐specific functions. The latter are induced by signals from the …
Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function
JL Brogdon, Y Xu, SJ Szabo, S An, F Buxton, D Cohen… - Blood, 2007 - ashpublications.org
Histone deacetylases (HDACs) play a critical role in regulating gene expression and key
biological processes. However, how HDACs are involved in innate immunity is little …
biological processes. However, how HDACs are involved in innate immunity is little …