Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets

S Dewanjee, S Das, AK Das, N Bhattacharjee… - European journal of …, 2018‏ - Elsevier
Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

[HTML][HTML] Morin hydrate: A comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential

SA Rajput, X Wang, HC Yan - Biomedicine & pharmacotherapy, 2021‏ - Elsevier
Flavonoids are natural plant-derived dietary bioactive compounds having a substantial
impact on human health. Morin hydrate is a bioflavonoid mainly obtained from fruits, stem …

Antioxidant phytochemicals as potential therapy for diabetic complications

OOP Akpoveso, EE Ubah, G Obasanmi - Antioxidants, 2023‏ - mdpi.com
The global prevalence of diabetes continues to increase partly due to rapid urbanization and
an increase in the aging population. Consequently, this is associated with a parallel …

Protective effects of morin against acrylamide-induced hepatotoxicity and nephrotoxicity: A multi-biomarker approach

FM Kandemir, S Yıldırım, S Kucukler… - Food and chemical …, 2020‏ - Elsevier
Acrylamide (ACR) is a heat-induced carcinogen substance that is found in some foods due
to cooking or other thermal processes. The aim of present study was to assess the probable …

The role of natural flavonoids on neuroinflammation as a therapeutic target for Alzheimer's disease: a narrative review

Q Zhang, Y Yan - Neural Regeneration Research, 2023‏ - journals.lww.com
Alzheimer's disease is a neurodegenerative disease that affects a large proportion of older
adult people and is characterized by memory loss, progressive cognitive impairment, and …

Anti-oxidative, anti-inflammatory and anti-apoptotic effects of flavonols: targeting Nrf2, NF-κB and p53 pathways in neurodegeneration

M Jazvinšćak Jembrek, N Oršolić, L Mandić, A Sadžak… - Antioxidants, 2021‏ - mdpi.com
Neurodegenerative diseases are one of the leading causes of disability and death
worldwide. Intracellular transduction pathways that end in the activation of specific …

[HTML][HTML] Nrf2 signaling in diabetic nephropathy, cardiomyopathy and neuropathy: Therapeutic targeting, challenges and future prospective

M Hashemi, MA Zandieh, S Ziaolhagh… - … et Biophysica Acta (BBA …, 2023‏ - Elsevier
Western lifestyle contributes to an overt increase in the prevalence of metabolic anomalies
including diabetes mellitus (DM) and obesity. Prevalence of DM is rapidly growing …

Morin attenuates ifosfamide-induced neurotoxicity in rats via suppression of oxidative stress, neuroinflammation and neuronal apoptosis

H Çelik, S Kucukler, S Çomaklı, S Özdemir… - Neurotoxicology, 2020‏ - Elsevier
Ifosfamide (IFA), a commonly used chemotherapeutic drug, has been frequently associated
with encephalopathy and central nervous system toxicity. The present study aims to …

Morin exhibits a neuroprotective effect in MPTP-induced Parkinson's disease model via TFEB/AMPK-mediated mitophagy

Z Wang, J Cui, D Li, S Ran, J Huang, G Chen - Phytomedicine, 2023‏ - Elsevier
Background Parkinson's disease (PD) is one of the most common neurodegenerative
diseases in the world. Mitophagy has been implicated in PD etiology for decades and its …

[HTML][HTML] Morin: a comprehensive review on its versatile biological activity and associated therapeutic potential in treating cancers

VKR Balaga, A Pradhan, R Thapa, N Patel… - Pharmacological …, 2023‏ - Elsevier
Introduction Herbal traditional medicines are used for the treatment of human diseases and
associated complications from the medieval periods. Flavonoids are naturally occurring …