Disease gene discovery in male infertility: past, present and future

MJ Xavier, A Salas-Huetos, MS Oud, KI Aston… - Human Genetics, 2021 - Springer
Identifying the genes causing male infertility is important to increase our biological
understanding as well as the diagnostic yield and clinical relevance of genetic testing in this …

Esrrb, an estrogen‐related receptor involved in early development, pluripotency, and reprogramming

N Festuccia, N Owens, P Navarro - FEBS letters, 2018 - Wiley Online Library
Estrogen‐related receptor b (Esrrb) is part of a family of three orphan nuclear receptors with
broad expression profiles and a generic function in regulating energy metabolism in …

[HTML][HTML] Single-cell RNA-sequencing reveals the transcriptional landscape of ND-42 mediated spermatid elongation via mitochondrial derivative maintenance in …

J Yu, Z Li, Y Fu, F Sun, X Chen, Q Huang, L He, H Yu… - Redox Biology, 2023 - Elsevier
During spermatogenesis, mitochondria extend along the whole length of spermatid tail and
offer a structural platform for microtubule reorganization and synchronized spermatid …

A RNA-Seq analysis to describe the boar sperm transcriptome and its seasonal changes

M Gòdia, M Estill, A Castelló, S Balasch… - Frontiers in …, 2019 - frontiersin.org
Understanding the molecular basis of cell function and ultimate phenotypes is crucial for the
development of biological markers. With this aim, several RNA-seq studies have been …

Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans

H Wu, L Sun, Y Wen, Y Liu, J Yu… - Proceedings of the …, 2016 - National Acad Sciences
Processing of pre-mRNA into mRNA is an important regulatory mechanism in eukaryotes
that is mediated by the spliceosome, a huge and dynamic ribonucleoprotein complex …

Structure and molecular basis of spermatid elongation in the Drosophila testis

Q Huang, X Chen, H Yu, L Ji, Y Shi… - Open …, 2023 - royalsocietypublishing.org
Spermatid elongation is a crucial event in the late stage of spermatogenesis in the
Drosophila testis, eventually leading to the formation of mature sperm after meiosis. During …

A chromosome-level assembly supports genome-wide investigation of the DMRT gene family in the golden mussel (Limnoperna fortunei)

JG RN Ferreira, J A. Americo, D LAS do Amaral… - …, 2023 - academic.oup.com
Abstract Background The golden mussel (Limnoperna fortunei) is a highly invasive species
that causes environmental and socioeconomic losses in invaded areas. Reference …

[HTML][HTML] The big bang of genome editing technology: development and application of the CRISPR/Cas9 system in disease animal models

S Ming, XU Tian-Rui, C Ce-Shi - Zoological Research, 2016 - ncbi.nlm.nih.gov
Targeted genome editing technology has been widely used in biomedical studies. The
CRISPR-associated RNA-guided endonuclease Cas9 has become a versatile genome …

Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in Drosophila testes

J Yu, X Lan, X Chen, C Yu, Y Xu, Y Liu, L Xu… - …, 2016 - journals.biologists.com
The homeostasis of self-renewal and differentiation in stem cells is controlled by intrinsic
signals and their niche. We conducted a large-scale RNA interference (RNAi) screen in …

Genetic factors influencing sperm competition

A Civetta, JM Ranz - Frontiers in genetics, 2019 - frontiersin.org
Females of many different species often mate with multiple males, creating opportunities for
competition among their sperm. Although originally unappreciated, sperm competition is …