Mass spectrometry imaging for clinical research–latest developments, applications, and current limitations

PM Vaysse, RMA Heeren, T Porta, B Balluff - Analyst, 2017 - pubs.rsc.org
Mass spectrometry is being used in many clinical research areas ranging from toxicology to
personalized medicine. Of all the mass spectrometry techniques, mass spectrometry …

Ambient ionization mass spectrometry for cancer diagnosis and surgical margin evaluation

DR Ifa, LS Eberlin - Clinical chemistry, 2016 - academic.oup.com
BACKGROUND There is a clinical need for new technologies that would enable rapid
disease diagnosis based on diagnostic molecular signatures. Ambient ionization mass …

Lipid and metabolite profiles of human brain tumors by desorption electrospray ionization-MS

AK Jarmusch, V Pirro, Z Baird… - Proceedings of the …, 2016 - National Acad Sciences
Examination of tissue sections using desorption electrospray ionization (DESI)-MS revealed
phospholipid-derived signals that differ between gray matter, white matter, gliomas …

Desorption electrospray ionization mass spectrometry imaging in discovery and development of novel therapies

T Soudah, A Zoabi, K Margulis - Mass Spectrometry Reviews, 2023 - Wiley Online Library
Desorption electrospray ionization mass spectrometry imaging (DESI‐MSI) is one of the
least specimen destructive ambient ionization mass spectrometry tissue imaging methods. It …

Clinical metabolomics: the new metabolic window for inborn errors of metabolism investigations in the post-genomic era

A Tebani, L Abily-Donval, C Afonso, S Marret… - International journal of …, 2016 - mdpi.com
Inborn errors of metabolism (IEM) represent a group of about 500 rare genetic diseases with
an overall estimated incidence of 1/2500. The diversity of metabolic pathways involved …

Advanced mass spectrometric and spectroscopic methods coupled with machine learning for in vitro diagnosis

X Chen, W Shu, L Zhao, J Wan - View, 2023 - Wiley Online Library
In vitro diagnosis (IVD) is one vital component of medical tests that detects biological
samples of tissues or bio‐fluids. Recently, mass spectrometry and spectroscopy have been …

Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI) in Disease Diagnosis: An Overview.

BS Kumar - Analytical Methods, 2023 - pubs.rsc.org
Tissue analysis, which is essential to histology and is considered the benchmark for the
diagnosis and prognosis of many illnesses, including cancer, is significant. During surgery …

Portable mass spectrometry system: instrumentation, applications, and path to 'omics analysis

J Wang, ME Pursell, A DeVor, O Awoyemi… - …, 2022 - Wiley Online Library
Mass spectrometry (MS) is an information rich analytical technique and plays a key role in
various 'omics studies. Standard mass spectrometers are bulky and operate at high vacuum …

Review and perspectives on the applications of mass spectrometry imaging under ambient conditions

CJ Perez, AK Bagga, SS Prova… - Rapid …, 2019 - Wiley Online Library
Ambient mass spectrometry (AMS)‐based techniques are performed under ambient
conditions in which the ionization and desorption occur in the open environment allowing …

Advances in ionization for mass spectrometry

PM Peacock, WJ Zhang, S Trimpin - Analytical chemistry, 2017 - ACS Publications
Integral to advances in mass spectrometry (MS) are developments in ionization technology,
which is constantly evolving because of advances in fundamental understanding …