Novel Gastroprotective and Thermostable Cocrystal of Dimethyl Fumarate: Its Preparation, Characterization, and In Vitro and In Vivo Evaluation
Crystallization has revolutionized the field of solid-state formulations by modulating the
physiochemical and release profile of active pharmaceutical ingredients (APIs). Dimethyl …
physiochemical and release profile of active pharmaceutical ingredients (APIs). Dimethyl …
Identification of sulfonamide based butyrylcholinesterase inhibitors through scaffold hop** approach
Butyrylcholinesterase (BChE), a hydrolytic enzyme, is responsible for the termination of the
action of acetylcholine besides acetylcholinesterase (AChE) in the synaptic cleft of the brain …
action of acetylcholine besides acetylcholinesterase (AChE) in the synaptic cleft of the brain …
Syringic acid, a novel thyroid hormone receptor‐β agonist, ameliorates propylthiouracil‐induced thyroid toxicity in rats
The aim of this study was to evaluate the potential of syringic acid (SA) against
propylthiouracil (PTU)‐induced hypothyroidism in rats. SA at a prestandardized dose, 50 …
propylthiouracil (PTU)‐induced hypothyroidism in rats. SA at a prestandardized dose, 50 …
Design, synthesis, molecular docking and pharmacological evaluation of some thiadiazole based nipecotic acid derivatives as a potential anticonvulsant and …
In our continuous effort to develop novel antiepileptic drug, a new series of nipecotic acid
derivatives having1, 3, 4-thiadiazole nucleus were designed and synthesized. This study …
derivatives having1, 3, 4-thiadiazole nucleus were designed and synthesized. This study …
Improved machine learning scoring functions for identification of Electrophorus electricus's acetylcholinesterase inhibitors
Abstract Structure-based drug design (SBDD) is an important in silico technique, used for
the identification of enzyme inhibitors. Acetylcholinesterase (AChE), obtained from …
the identification of enzyme inhibitors. Acetylcholinesterase (AChE), obtained from …
Identification of sulfonamide-based butyrylcholinesterase inhibitors using machine learning
Aim: This study reports the designing of BChE inhibitors through machine learning (ML),
followed by in silico and in vitro evaluations. Methodology: ML technique was used to predict …
followed by in silico and in vitro evaluations. Methodology: ML technique was used to predict …
Development of homology model, docking protocol and Machine-Learning based scoring functions for identification of Equus caballus's butyrylcholinesterase …
Abstract Machine learning (ML), an emerging field in drug design, has the potential to
predict in silico toxicity, shape-based analysis of inhibitors, scoring function (SF) etc. In the …
predict in silico toxicity, shape-based analysis of inhibitors, scoring function (SF) etc. In the …
Effect of sulfonamide derivatives of phenylglycine on scopolamine‐induced amnesia in rats
Alzheimer's disease is a neurodegenerative disease responsible for dementia and other
neuropsychiatric symptoms. In the present study, compounds 30 and 33, developed earlier …
neuropsychiatric symptoms. In the present study, compounds 30 and 33, developed earlier …
[HTML][HTML] Neuropharmacological Assessment of Sulfonamide Derivatives of Para-Aminobenzoic Acid through In Vivo and In Silico Approaches
Background/Objectives: Alzheimer's disease (AD), a complex neurogenerative disorder,
manifests as dementia and concomitant neuropsychiatric symptoms, including apathy …
manifests as dementia and concomitant neuropsychiatric symptoms, including apathy …
Lycopene potentiates wound healing in streptozotocin-induced diabetic rats
Background Diabetes is a growing metabolic disease that is characterized by high blood
sugar levels with life-threatening results. Diabetic wounds are a major problem because …
sugar levels with life-threatening results. Diabetic wounds are a major problem because …