Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer

H Paganetti - Physics in Medicine & Biology, 2014 - iopscience.iop.org
Proton therapy treatments are based on a proton RBE (relative biological effectiveness)
relative to high-energy photons of 1.1. The use of this generic, spatially invariant RBE within …

Nuclear physics in particle therapy: a review

M Durante, H Paganetti - Reports on Progress in Physics, 2016 - iopscience.iop.org
Charged particle therapy has been largely driven and influenced by nuclear physics. The
increase in energy deposition density along the ion path in the body allows reducing the …

TOPAS: an innovative proton Monte Carlo platform for research and clinical applications

J Perl, J Shin, J Schümann, B Faddegon… - Medical …, 2012 - Wiley Online Library
Purpose: While Monte Carlo particle transport has proven useful in many areas (treatment
head design, dose calculation, shielding design, and imaging studies) and has been …

Range uncertainties in proton therapy and the role of Monte Carlo simulations

H Paganetti - Physics in Medicine & Biology, 2012 - iopscience.iop.org
The main advantages of proton therapy are the reduced total energy deposited in the patient
as compared to photon techniques and the finite range of the proton beam. The latter adds …

A review of the use and potential of the GATE Monte Carlo simulation code for radiation therapy and dosimetry applications

D Sarrut, M Bardiès, N Boussion, N Freud… - Medical …, 2014 - Wiley Online Library
In this paper, the authors' review the applicability of the open‐source GATE Monte Carlo
simulation platform based on the GEANT4 toolkit for radiation therapy and dosimetry …

A phenomenological relative biological effectiveness (RBE) model for proton therapy based on all published in vitro cell survival data

AL McNamara, J Schuemann… - Physics in Medicine & …, 2015 - iopscience.iop.org
Proton therapy treatments are currently planned and delivered using the assumption that the
proton relative biological effectiveness (RBE) relative to photons is 1.1. This assumption …

[SÁCH][B] Monte Carlo techniques in radiation therapy

J Seco, F Verhaegen - 2013 - api.taylorfrancis.com
Monte Carlo simulation techniques made a slow entry in the field of radiotherapy in the late
1970s. Since then they have gained enormous popularity, judging by the number of papers …

Patient study of in vivo verification of beam delivery and range, using positron emission tomography and computed tomography imaging after proton therapy

K Parodi, H Paganetti, HA Shih, S Michaud… - International Journal of …, 2007 - Elsevier
Purpose: To investigate the feasibility and value of positron emission tomography and
computed tomography (PET/CT) for treatment verification after proton radiotherapy. Methods …

Clinical implementation of full Monte Carlo dose calculation in proton beam therapy

H Paganetti, H Jiang, K Parodi… - Physics in Medicine …, 2008 - iopscience.iop.org
The goal of this work was to facilitate the clinical use of Monte Carlo proton dose calculation
to support routine treatment planning and delivery. The Monte Carlo code Geant4 was used …

Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning

C Grassberger, A Trofimov, A Lomax… - International Journal of …, 2011 - Elsevier
PURPOSE: To calculate the linear energy transfer (LET) distributions in patients undergoing
proton therapy. These distributions can be used to identify areas of elevated or diminished …