Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …

Large-scale genome-wide association studies conducted over the last decade have
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …

This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …

version of the Guidelines, which is freely available via the ESC and EAS websites and
hosted on their journals' websites (EHJ and Atherosclerosis Journal). The National Cardiac …

Background Inclisiran, an siRNA administered twice-yearly, significantly reduced LDL
cholesterol (LDL-C) in Phase III trials. Whether lowering LDL-C with inclisiran translates into …

Background Circulating lipoprotein lipids cause coronary heart disease (CHD). However,
the precise way in which one or more lipoprotein lipid-related entities account for this …

There is now overwhelming evidence to support lowering LDL-c (low-density lipoprotein
cholesterol) to reduce cardiovascular morbidity and mortality. Statins are a class of drugs …

Background Incident cardiovascular disease (CVD) increases with increasing low-density
lipoprotein cholesterol (LDL-C) concentration and exposure duration. Area under the LDL-C …

One in 4 Americans> 40 years of age takes a statin to reduce the risk of myocardial
infarction, ischemic stroke, and other complications of atherosclerotic disease. The most …

Immune-mediated necrotizing myopathy (IMNM) is a group of inflammatory myopathies that
was distinguished from polymyositis in 2004. Most IMNMs are associated with anti-signal …