The zebrafish has become a prominent vertebrate model for disease and has already
contributed to several examples of successful phenotype-based drug discovery. For the …

The zebrafish is a recent addition to animal models of human cancer, and studies using this
model are rapidly contributing major insights. Zebrafish develop cancer spontaneously, after …

NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical
for regulation of intracellular iron bioavailability. However, how ferritinophagy flux is …

CRISPR/Cas9 technology of genome editing has greatly facilitated the targeted inactivation
of genes in vitro and in vivo in a wide range of organisms. In zebrafish, it allows the rapid …

Hematopoiesis is a complex process with a variety of different signaling pathways
influencing every step of blood cell formation from the earliest precursors to final …

Haem is an iron-containing tetrapyrrole that is critical for a variety of cellular and
physiological processes,–. Haem binding proteins are present in almost all cellular …

Tissue-specific stem cells persist for a lifetime and can differentiate to maintain homeostasis
or transform to initiate cancer. Despite their importance, there are no described quality …

The success of marker-based approaches for dissecting haematopoiesis in mouse and
human is reliant on the presence of well-defined cell surface markers specific for diverse …

Multiple human diseases ensue from a hereditary or acquired deficiency of iron-transporting
protein function that diminishes transmembrane iron flux in distinct sites and directions …

The zebrafish has proven to be a valuable model organism for studying hematopoiesis, but
relatively little is known about zebrafish immune cell development and functional diversity …