A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications
Post-acute sequelae of COVID (PASC), usually referred to as 'Long COVID'(a phenotype of
COVID-19), is a relatively frequent consequence of SARS-CoV-2 infection, in which …
COVID-19), is a relatively frequent consequence of SARS-CoV-2 infection, in which …
Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases
Most non-communicable diseases involve inflammatory changes in one or more vascular
systems, and there is considerable evidence that unliganded iron plays major roles in this …
systems, and there is considerable evidence that unliganded iron plays major roles in this …
Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC)
Background Fibrin (ogen) amyloid microclots and platelet hyperactivation previously
reported as a novel finding in South African patients with the coronavirus 2019 disease …
reported as a novel finding in South African patients with the coronavirus 2019 disease …
Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide
It is well known that a variety of inflammatory diseases are accompanied by
hypercoagulability, and a number of more-or-less longer-term signalling pathways have …
hypercoagulability, and a number of more-or-less longer-term signalling pathways have …
[HTML][HTML] Combined triple treatment of fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC) can …
E Pretorius, C Venter, GJ Laubscher, MJ Kotze… - 2021 - europepmc.org
We recognise that fibrin (ogen) amyloid microclots and platelet hyperactivation, that we have
previously observed in COVID-19 and Long COVID/Post-Acute Sequelae of COVID-19 …
previously observed in COVID-19 and Long COVID/Post-Acute Sequelae of COVID-19 …
The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin (ogen)
Although the two phenomena are usually studied separately, we summarise a considerable
body of literature to the effect that a great many diseases involve (or are accompanied by) …
body of literature to the effect that a great many diseases involve (or are accompanied by) …
Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin …
We have noted in previous work, in a variety of inflammatory diseases, where iron
dysregulation occurs, a strong tendency for erythrocytes to lose their normal discoid shape …
dysregulation occurs, a strong tendency for erythrocytes to lose their normal discoid shape …
Eryptosis as a marker of Parkinson's disease
A major trend in recent Parkinson's disease (PD) research is the investigation of biological
markers that could help in identifying at-risk individuals or to track disease progression and …
markers that could help in identifying at-risk individuals or to track disease progression and …
Evaluation of fibrin-based interpenetrating polymer networks as potential biomaterials for tissue engineering
O Gsib, JL Duval, M Goczkowski, M Deneufchatel… - Nanomaterials, 2017 - mdpi.com
Interpenetrating polymer networks (IPNs) have gained great attention for a number of
biomedical applications due to their improved properties compared to individual …
biomedical applications due to their improved properties compared to individual …
An investigation into the pleiotropic activity of metformin. A glimpse of haemostasis
M Markowicz-Piasecka, A Sadkowska… - European Journal of …, 2020 - Elsevier
The most characteristic features of type 2 diabetes mellitus (T2DM) are hyperglycaemia and
insulin resistance, however, patients with T2DM are at higher risk of cardiovascular disease …
insulin resistance, however, patients with T2DM are at higher risk of cardiovascular disease …