HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

The loss of control over drug intake that occurs in addiction was initially believed to result
from disruption of subcortical reward circuits. However, imaging studies in addictive …

Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex
human behaviors such as evaluation, affect regulation and reward-based decision-making …

This study relies on knowledge regarding the neuroplasticity of dual-system components
that govern addiction and excessive behavior and suggests that alterations in the grey …

We review the literature on interoception as it relates to depression and anxiety, with a focus
on belief, and alliesthesia. The connection between increased but noisy afferent …

Rationale Pathological gambling (PG) has recently been considered as a “behavioral” or
nonsubstance addiction. A comparison of the characteristics of PG and substance use …

Most substance abusers simultaneously use and abuse more than one substance, even
when there is a clear drug of choice. This pattern creates a great challenge in relating …

The ERN is a negative deflection in the event-related potential that peaks approximately 50
ms after the commission of an error. The ERN is thought to reflect early error-processing …

Gambling is a prevalent recreational behaviour. Approximately 5% of adults have been
estimated to experience problems with gambling. The most severe form of gambling …

Impulse control disorders (ICDs), including pathological gambling, trichotillomania,
kleptomania and others, have been conceptualized to lie along an impulsive–compulsive …