Socioeconomic aspects of incretin-based therapy

T Karagiannis, E Bekiari, A Tsapas - Diabetologia, 2023 - Springer
Incretin-based therapies, particularly glucagon-like peptide-1 receptor agonists (GLP-1
RAs), have demonstrated cardiovascular benefits in people with type 2 diabetes. However …

SGLT2 inhibitors–the new standard of Care for Cardiovascular, renal and metabolic protection in type 2 diabetes: a narrative review

S Seidu, V Alabraba, S Davies, P Newland-Jones… - Diabetes Therapy, 2024 - Springer
A substantial evidence base supports the use of sodium-glucose cotransporter-2 inhibitors
(SGLT2is) in the treatment of type 2 diabetes mellitus (T2DM). This class of medicines has …

Cardiovascular safety in type 2 diabetes with sulfonylureas as second-line drugs: a nationwide population-based comparative safety study

H Wang, RLM Cordiner, Y Huang, L Donnelly… - Diabetes …, 2023 - diabetesjournals.org
OBJECTIVE To assess the real-world cardiovascular (CV) safety for sulfonylureas (SU), in
comparison with dipeptidyl peptidase 4 inhibitors (DPP4i) and thiazolidinediones (TZD) …

Underuse of GLP-1 receptor agonists in the management of type 2 diabetes despite a favorable benefit-safety profile

AJ Scheen - Expert Opinion on Drug Safety, 2024 - Taylor & Francis
Introduction Patients with type 2 diabetes (T2DM) are at high risk of atherosclerotic
cardiovascular disease (ASCVD) and cardiovascular death. Cardiovascular protection is a …

Bridging the gap in cardiovascular care in diabetic patients: are cardioprotective antihyperglycemic agents underutilized?

AJ Scheen - Expert Review of Clinical Pharmacology, 2023 - Taylor & Francis
Introduction Atherosclerotic cardiovascular disease (ASCVD) and heart failure (HF) are two
major complications of type 2 diabetes (T2DM). Cardiovascular protection is a key objective …

Lipid-lowering strategies for primary prevention of coronary heart disease in the UK: a cost-effectiveness analysis

JI Morton, C Marquina, M Lloyd, GF Watts… - …, 2024 - Springer
Aim We aimed to assess the cost effectiveness of four different lipid-lowering strategies for
primary prevention of coronary heart disease initiated at ages 30, 40, 50, and 60 years from …

GLP-1 receptor agonists and SGLT2 inhibitors in type 2 diabetes: pleiotropic cardiometabolic effects and add-on value of a combined therapy

AJ Scheen - Drugs, 2024 - Springer
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2
inhibitors (SGLT2is) have proven efficacy and safety in randomized clinical trials and …

Do SGLT2 inhibitors and GLP-1 receptor agonists modulate differently the risk of stroke? Discordance between randomised controlled trials and observational studies

AJ Scheen - Diabetes & Metabolism, 2023 - Elsevier
Stroke represents a major burden in patients with type 2 diabetes, yet this cerebrovascular
complication has been less carefully investigated than the risk of cardiovascular mortality …

The current role of SGLT2 inhibitors in type 2 diabetes and beyond: a narrative review

AJ Scheen - Expert Review of Endocrinology & Metabolism, 2023 - Taylor & Francis
Introduction Sodium-glucose cotransporter 2 inhibitors (SGLT2is, gliflozins), the most recent
oral antihyperglycaemic agents, provide a cardiorenal protection, an effect independent of …

Utilization and cost of non‐insulin glucose‐lowering drugs in Australia from 2013 to 2023

PS Hamblin, A Earnest, AW Russell… - Diabetes, Obesity …, 2024 - Wiley Online Library
Objectives To investigate the utilization and costs of non‐insulin glucose‐lowering drugs
(GLDs) in Australia from 2013 to 2023. Materials and Methods We conducted a retrospective …