Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials

EE Patton, LI Zon, DM Langenau - Nature reviews Drug discovery, 2021 - nature.com
Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …

Zebrafish larvae as a behavioral model in neuropharmacology

RM Basnet, D Zizioli, S Taweedet, D Finazzi, M Memo - Biomedicines, 2019 - mdpi.com
Zebrafish larvae show a clear and distinct pattern of swimming in response to light and dark
conditions, following the development of a swim bladder at 4 days post fertilization. This …

Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics

X Strakosas, H Biesmans, T Abrahamsson, K Hellman… - Science, 2023 - science.org
Interfacing electronics with neural tissue is crucial for understanding complex biological
functions, but conventional bioelectronics consist of rigid electrodes fundamentally …

[HTML][HTML] Toxicological effects of 6PPD and 6PPD quinone in zebrafish larvae

S Varshney, AH Gora, P Siriyappagouder… - Journal of Hazardous …, 2022 - Elsevier
Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is the most widely
used antioxidant in automobile tyres and many rubber products. We investigated the impact …

Synthetic azo-dye, Tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos

B Haridevamuthu, R Murugan, B Seenivasan… - Journal of Hazardous …, 2024 - Elsevier
Abstract Tartrazine (TZ), or E 102 or C Yellow, is a commonly used azo dye in the food and
dyeing industries. Its excessive usage beyond permissible levels threatens human health …

Acute toxic effects of polyethylene microplastic on adult zebrafish

CW Mak, KCF Yeung, KM Chan - Ecotoxicology and environmental safety, 2019 - Elsevier
To identify the physical effects, behavioral changes, and gene expression profiles of the
phase 1 detoxification-related gene (cyp 1a) and oogenesis-related gene (vtg 1) induced by …

Zebrafish as a successful animal model for screening toxicity of medicinal plants

A Modarresi Chahardehi, H Arsad, V Lim - Plants, 2020 - mdpi.com
The zebrafish (Danio rerio) is used as an embryonic and larval model to perform in vitro
experiments and developmental toxicity studies. Zebrafish may be used to determine the …

Making waves: New developments in toxicology with the zebrafish

KA Horzmann, JL Freeman - Toxicological Sciences, 2018 - academic.oup.com
The laboratory zebrafish (Danio rerio) is now an accepted model in toxicologic research.
The zebrafish model fills a niche between in vitro models and mammalian biomedical …

Zebrafish as an emerging model for studying complex brain disorders

AV Kalueff, AM Stewart, R Gerlai - Trends in pharmacological sciences, 2014 - cell.com
The zebrafish (Danio rerio) is rapidly becoming a popular model organism in
pharmacogenetics and neuropharmacology. Both larval and adult zebrafish are currently …

Zebrafish models for translational neuroscience research: from tank to bedside

AM Stewart, O Braubach, J Spitsbergen, R Gerlai… - Trends in …, 2014 - cell.com
The zebrafish (Danio rerio) is emerging as a new important species for studying
mechanisms of brain function and dysfunction. Focusing on selected central nervous system …