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Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials
EE Patton, LI Zon, DM Langenau - Nature reviews Drug discovery, 2021 - nature.com
Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …
Zebrafish larvae as a behavioral model in neuropharmacology
Zebrafish larvae show a clear and distinct pattern of swimming in response to light and dark
conditions, following the development of a swim bladder at 4 days post fertilization. This …
conditions, following the development of a swim bladder at 4 days post fertilization. This …
Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics
Interfacing electronics with neural tissue is crucial for understanding complex biological
functions, but conventional bioelectronics consist of rigid electrodes fundamentally …
functions, but conventional bioelectronics consist of rigid electrodes fundamentally …
[HTML][HTML] Toxicological effects of 6PPD and 6PPD quinone in zebrafish larvae
Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is the most widely
used antioxidant in automobile tyres and many rubber products. We investigated the impact …
used antioxidant in automobile tyres and many rubber products. We investigated the impact …
Synthetic azo-dye, Tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos
Abstract Tartrazine (TZ), or E 102 or C Yellow, is a commonly used azo dye in the food and
dyeing industries. Its excessive usage beyond permissible levels threatens human health …
dyeing industries. Its excessive usage beyond permissible levels threatens human health …
Acute toxic effects of polyethylene microplastic on adult zebrafish
CW Mak, KCF Yeung, KM Chan - Ecotoxicology and environmental safety, 2019 - Elsevier
To identify the physical effects, behavioral changes, and gene expression profiles of the
phase 1 detoxification-related gene (cyp 1a) and oogenesis-related gene (vtg 1) induced by …
phase 1 detoxification-related gene (cyp 1a) and oogenesis-related gene (vtg 1) induced by …
Zebrafish as a successful animal model for screening toxicity of medicinal plants
The zebrafish (Danio rerio) is used as an embryonic and larval model to perform in vitro
experiments and developmental toxicity studies. Zebrafish may be used to determine the …
experiments and developmental toxicity studies. Zebrafish may be used to determine the …
Making waves: New developments in toxicology with the zebrafish
The laboratory zebrafish (Danio rerio) is now an accepted model in toxicologic research.
The zebrafish model fills a niche between in vitro models and mammalian biomedical …
The zebrafish model fills a niche between in vitro models and mammalian biomedical …
Zebrafish as an emerging model for studying complex brain disorders
The zebrafish (Danio rerio) is rapidly becoming a popular model organism in
pharmacogenetics and neuropharmacology. Both larval and adult zebrafish are currently …
pharmacogenetics and neuropharmacology. Both larval and adult zebrafish are currently …
Zebrafish models for translational neuroscience research: from tank to bedside
The zebrafish (Danio rerio) is emerging as a new important species for studying
mechanisms of brain function and dysfunction. Focusing on selected central nervous system …
mechanisms of brain function and dysfunction. Focusing on selected central nervous system …