Abstract Background Pentavalent antimonials (Sb (V)) such as meglumine antimoniate
(Glucantime®) and sodium stibogluconate (Pentostam®) are used as first‐line treatments for …

Trypanosomatids are the causative agents of African slee** sickness, Chagas' disease,
and the different forms of leishmaniasis. This family of protozoan parasite possesses a …

The important protozoan parasites including Plasmodium, Leishmania, Toxoplasma,
Trypanosoma and Giardia have been proved as the main reason initiating and develo** …

Computational approaches represent valuable and essential tools in each step of the drug
discovery and development trajectory. Several computational methodologies are suitable to …

Lesihmaniasis is one of the major neglected tropical disease caused by the parasite of the
genus Leishmania. The disease has more than one clinical forms and the visceral form is …

In trypanosomatids, polyamine and trypanothione pathways can be considered as a whole
unique metabolism, where most enzymes are essential for parasitic survival and infectivity …

Leishmaniasis is one of the six diseases regarded most neglected by World Health
Organization which is predominant in develo** countries. Clinically, among the different …

Trypanothione reductase (TR) is considered to be one of the best targets to find new drugs
against Leishmaniasis. This enzyme is fundamental for parasite survival in the host since it …

In the vast majority of malignancies, the p53 tumor suppressor pathway is compromised. In
some cancer cells, high levels of MDM2 polyubiquitinate p53 and mark it for destruction …

Quercetin related compounds were tested against Leishmania amazonensis arginase, a
potential target for the development of new approaches in treating leishmaniasis. The IC50 …