An important host defence mechanism against pathogens is intracellular killing, which is
achieved through phagocytosis, a cellular process for engulfing and neutralizing …

Lipids are a big family of molecules with a vast number of functions in the cell membranes,
within the cytoplasm, and extracellularly. Lipid droplets (LDs) are the most common storage …

Background & Aims As the first approved medication for metabolic dysfunction-associated
steatohepatitis (MASH), the thyroid hormone receptor-β (THR-β) agonist MGL-3196 …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcriptional regulator of antioxidant
and anti-inflammatory response in all cell types. It also activates the transcription of genes …

Background Intracerebral hemorrhage (ICH) is a severe brain-injured disease accompanied
by cerebral edema, inflammation, and subsequent neurological deficits. Mesenchymal stem …

The tremendous potential of trehalose glycolipids as vaccine adjuvants has incentivized the
study of how the structures of these ligands relate to their Mincle-mediated agonist activities …

Lectin–glycan interactions play a crucial role in the immune system. An important class of
lectins in the innate immune system is myeloid C-type lectin receptors (CLRs). Myeloid …

As an environmental pollutant, ambient fine particulate matter (PM 2.5) was linked to
cardiovascular diseases. The molecular mechanisms underlying PM 2.5-induced …

Innate immune receptors that form complexes with secondary receptors, activating multiple
signalling pathways, modulate cellular activation and play essential roles in regulating …