Structural basis of nucleosome transcription mediated by Chd1 and FACT

L Farnung, M Ochmann, M Engeholm… - Nature Structural & …, 2021 - nature.com
Efficient transcription of RNA polymerase II (Pol II) through nucleosomes requires the help of
various factors. Here we show biochemically that Pol II transcription through a nucleosome …

A fluorescent multi-domain protein reveals the unfolding mechanism of Hsp70

S Tiwari, B Fauvet, S Assenza, P De Los Rios… - Nature Chemical …, 2023 - nature.com
Detailed understanding of the mechanism by which Hsp70 chaperones protect cells against
protein aggregation is hampered by the lack of a comprehensive characterization of the …

Active unfolding of the glucocorticoid receptor by the Hsp70/Hsp40 chaperone system in single-molecule mechanical experiments

P Moessmer, T Suren, U Majdic… - Proceedings of the …, 2022 - National Acad Sciences
The glucocorticoid receptor (GR) is an important transcription factor and drug target linked to
a variety of biological functions and diseases. It is one of the most stringent physiological …

The role and mechanisms of the two‐component system EnvZ/OmpR on the intracellular survival of Aeromonas hydrophila

Z Du, M Zhang, Y Qin, L Zhao, L Huang… - Journal of Fish …, 2022 - Wiley Online Library
Aeromonas hydrophila infections are common in aquaculture. Our previous studies found
that the A. hydrophila B11 strain can survive in fish macrophages for at least 24 h and the …

Quantitative Proteomic Analysis on the Slightly Acidic Electrolyzed Water Triggered Viable but Non-Culturable Listeria monocytogenes

HY Chang, CY Gui, TC Huang, YC Hung… - International journal of …, 2023 - mdpi.com
This study undertakes a comprehensive exploration of the impact of slightly acidic
electrolyzed water (SAEW) on Listeria monocytogenes, a common foodborne pathogen, with …

Functional effects of ARV-1502 analogs against bacterial Hsp70 and implications for antimicrobial activity

A Brakel, L Kolano, CN Kraus, L Otvos Jr… - Frontiers in …, 2022 - frontiersin.org
The antimicrobial peptide (AMP) ARV-1502 was designed based on naturally occurring
short proline-rich AMPs, including pyrrhocoricin and drosocin. Identification of chaperone …

Recombinant Tumor Suppressor TSC1 Differentially Interacts with Escherichia coli DnaK and Human HSP70

N Natarajan, A Shaik, V Thiruvenkatam - ACS omega, 2020 - ACS Publications
Tuberous sclerosis complex (TSC) is a neurological syndrome manifested by non-
cancerous tumors in several organs. Mutations in either TSC1 or TSC2 tumor suppressor …

A novel fluorescent multi-domain protein construct reveals the individual steps of the unfoldase action of Hsp70

S Tiwari, B Fauvet, S Assenza, P De los Rios… - bioRxiv, 2022 - biorxiv.org
A detailed understanding of the mechanism by which Hsp70 chaperones protect cells
against protein aggregation is hampered by the detailed characterization of the aggregates …

Benefits and challenges of the secretory pathways of Bacillus subtilis to biotechnology

S Couperus - 2020 - fse.studenttheses.ub.rug.nl
This essay discusses the two main secretion pathways of Bacillus subtilis. The inidividual
components and their interactions, as well as chaperones and extracellular proteases are …