Combining machine learning and nanofluidic technology to diagnose pancreatic cancer using exosomes

J Ko, N Bhagwat, SS Yee, N Ortiz, A Sahmoud… - ACS …, 2017 - ACS Publications
Circulating exosomes contain a wealth of proteomic and genetic information, presenting an
enormous opportunity in cancer diagnostics. While microfluidic approaches have been used …

Diagnosis of traumatic brain injury using miRNA signatures in nanomagnetically isolated brain-derived extracellular vesicles

J Ko, M Hemphill, Z Yang, E Sewell, YJ Na… - Lab on a Chip, 2018 - pubs.rsc.org
The accurate diagnosis and clinical management of traumatic brain injury (TBI) is currently
limited by the lack of accessible molecular biomarkers that reflect the pathophysiology of this …

A magnetic micropore chip for rapid (< 1 hour) unbiased circulating tumor cell isolation and in situ RNA analysis

J Ko, N Bhagwat, SS Yee, T Black, C Redlinger… - Lab on a Chip, 2017 - pubs.rsc.org
The use of microtechnology for the highly selective isolation and sensitive detection of
circulating tumor cells has shown enormous promise. One challenge for this technology is …

[HTML][HTML] Optimized process for the fabrication of PDMS membranes integrating permanent micro-magnet arrays

L Descamps, S Mekkaoui, MC Audry, AL Deman… - AIP Advances, 2020 - pubs.aip.org
Here we report on the fabrication of micro-magnet arrays by powder agglomeration in a
polymer matrix. The NdFeB@ polydimethylsiloxane (PDMS) inner microstructure and the …

Laser‐Patterning of Micromagnets for Immuno‐Magnetophoretic Exosome Capture

JH Molinski, S Parwal, JXJ Zhang - Small Methods, 2024 - Wiley Online Library
Efficient isolation and patterning of biomolecules is a vital step within sample preparation for
biomolecular analysis, with numerous diagnostic and therapeutic applications. For …

A comparative study of Ni75Fe25 microcomponents fabricated by microelectroforming and micromolding

B Zhou, B Su, M Li, A Zhang, J Han, J Meng - Journal of Materials …, 2021 - Elsevier
NiFe alloy microcomponents are widely used in electromagnetic devices and
microelectromechanical systems due to high saturation magnetization and low coercivity. In …

[КНИГА][B] Microfluidic Devices for High-Resolution Cellular Profiling

P Aldridge - 2019 - search.proquest.com
Rapid and accurate detection, quantification and analysis of rare cells in biological samples
is of critical importance for a variety of clinical applications. These cells, which can be …

[КНИГА][B] Diagnosing Disease Using High Throughput Parallelized Nanofluidics and Machine Learning

JA Ko - 2018 - search.proquest.com
I have developed microchip-based diagnostic platforms to enrich for specific rare blood
based cells and extracellular vesicles and extract useful clinical diagnoses and prognoses …

[КНИГА][B] Microlamination Based Lumped and Distributed Magnetic MEMS Systems Enabled by Through-Mold Sequential Multilayer Electrodeposition Technology

Y Li - 2018 - search.proquest.com
Microfabricated magnetic MEMS components such as permanent micromagnets and soft
magnetic structures are key enablers in various lumped and distributed systems such as …

A Cell-Based Approach to Early Pancreatic Cancer Detection

BZ Stanger… - 2017 - apps.dtic.mil
The goal of this proposal was to develop enhanced techniques for isolating and
characterizing circulating epithelial cells CECs from the blood of mice or human patients …