The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer.
Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has …

Genome sequencing and gene expression analyses of prostate tumours have highlighted
the potential importance of genetic and epigenetic changes observed in WNT signalling …

The analysis of exonic DNA from prostate cancers has identified recurrently mutated genes,
but the spectrum of genome-wide alterations has not been profiled extensively in this …

Prostate cancer rates vary substantially by race, ethnicity, and geography. These disparities
can be explained by variation in access to screening and treatment, variation in exposure to …

Genome-wide association studies (GWAS) have identified 76 variants associated with
prostate cancer risk predominantly in populations of European ancestry. To identify …

Standardized and reproducible preclinical models that recapitulate the dynamics of prostate
cancer are urgently needed. We established a bank of transplantable patient-derived …

DNA double-strand breaks (DSBs) can lead to the development of genomic rearrangements,
which are hallmarks of cancer. Fusions between TMPRSS2, encoding the transmembrane …

TMPRSS2-ERG gene fusions are the predominant molecular subtype of prostate cancer.
Here, we explored the role of TMPRSS2-ERG gene fusion product using in vitro and in vivo …

Chromosomal translocations involving the ERG locus are frequent events in human prostate
cancer pathogenesis; however, the biological role of aberrant ERG expression is …

The discovery of recurrent gene fusions in a majority of prostate cancers has important
clinical and biological implications in the study of common epithelial tumours. Gene fusion …