Molecular innovations in plant TIR-based immunity signaling
A protein domain (Toll and Interleukin-1 receptor [TIR]-like) with homology to animal TIRs
mediates immune signaling in prokaryotes and eukaryotes. Here, we present an overview of …
mediates immune signaling in prokaryotes and eukaryotes. Here, we present an overview of …
[HTML][HTML] Bifurcation of signalling in human innate immune pathways to NF-kB and IRF family activation
A Kusiak, G Brady - Biochemical Pharmacology, 2022 - Elsevier
The human innate immune response can be activated through a wide range of stimuli. This
multi-faceted system can be triggered by a range of immunostimulants including pathogen …
multi-faceted system can be triggered by a range of immunostimulants including pathogen …
Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling
Cyclic adenosine diphosphate (ADP)–ribose (cADPR) isomers are signaling molecules
produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide …
produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide …
[HTML][HTML] Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules
The NADase SARM1 (sterile alpha and TIR motif containing 1) is a key executioner of axon
degeneration and a therapeutic target for several neurodegenerative conditions. We show …
degeneration and a therapeutic target for several neurodegenerative conditions. We show …
Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute
X Gao, K Shang, K Zhu, L Wang, Z Mu, X Fu, X Yu… - Nature, 2024 - nature.com
Argonaute (Ago) proteins mediate RNA-or DNA-guided inhibition of nucleic acids,. Although
the mechanisms used by eukaryotic Ago proteins and long prokaryotic Ago proteins (pAgos) …
the mechanisms used by eukaryotic Ago proteins and long prokaryotic Ago proteins (pAgos) …
Activation of Thoeris antiviral system via SIR2 effector filament assembly
To survive bacteriophage (phage) infections, bacteria developed numerous anti-phage
defence systems,,,,,–. Some of them (for example, type III CRISPR–Cas, CBASS, Pycsar and …
defence systems,,,,,–. Some of them (for example, type III CRISPR–Cas, CBASS, Pycsar and …
Ab initio phasing macromolecular structures using electron-counted MicroED data
Structures of two globular proteins were determined ab initio using microcrystal electron
diffraction (MicroED) data that were collected on a direct electron detector in counting mode …
diffraction (MicroED) data that were collected on a direct electron detector in counting mode …
Benchmarking the ideal sample thickness in cryo-EM
The relationship between sample thickness and quality of data obtained is investigated by
microcrystal electron diffraction (MicroED). Several electron microscopy (EM) grids …
microcrystal electron diffraction (MicroED). Several electron microscopy (EM) grids …
Schisandrin B attenuates diabetic cardiomyopathy by targeting MyD88 and inhibiting MyD88‐dependent inflammation
W Luo, K Lin, J Hua, J Han, Q Zhang, L Chen… - Advanced …, 2022 - Wiley Online Library
Diabetes manifests as chronic inflammation and leads to the development diabetic
cardiomyopathy (DCM). Targeting key proteins in inflammatory signaling may provide new …
cardiomyopathy (DCM). Targeting key proteins in inflammatory signaling may provide new …
Protein-based adjuvants for vaccines as immunomodulators of the innate and adaptive immune response: Current knowledge, challenges, and future opportunities
DA Díaz-Dinamarca, ML Salazar, BN Castillo… - Pharmaceutics, 2022 - mdpi.com
New-generation vaccines, formulated with subunits or nucleic acids, are less immunogenic
than classical vaccines formulated with live-attenuated or inactivated pathogens. This …
than classical vaccines formulated with live-attenuated or inactivated pathogens. This …