Key early features of amyotrophic lateral sclerosis (ALS) are denervation of neuromuscular
junctions and axonal degeneration. Motor neuron homeostasis relies on local translation …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative
disorder, characterized by selective loss of motor neurons (MNs). A number of causative …

Dysfunction of the RNA-binding protein (RBP) FUS implicated in RNA metabolism can
cause amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. Mutations …

Autosomal dominant mutations in the gene encoding the DNA and RNA binding protein FUS
are a cause of amyotrophic lateral sclerosis (ALS), and about 0· 3–0· 9% of patients with …

Importin β-superfamily nuclear import receptors (NIRs) mitigate mislocalization and
aggregation of RNA-binding proteins (RBPs), like FUS and TDP-43, which are implicated in …

Cytoplasmic mislocalization of the nuclear Fused in Sarcoma (FUS) protein is associated to
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS …

Few studies have investigated the properties and protein composition of small extracellular
vesicles (sEVs) derived from neurons under hypoxic conditions. Presently, the extent of the …

Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder characterized by
progressive skeletal muscle denervation and loss of motor neurons that results in muscle …

Mutations that disrupt the function of the DNA/RNA-binding protein FUS could cause
amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. One of the key …

ABSTRACT A major challenge for understanding and treating Amyotrophic Lateral Sclerosis
(ALS) is that most patients have no known genetic cause. Even within defined genetic …