Advanced glycation end products (AGEs) are potentially harmful and heterogeneous
molecules derived from nonenzymatic glycation. The pathological implications of AGEs are …

The tripeptide glutathione is the thiol compound present in the highest concentration in cells
of all organs. Glutathione has many physiological functions including its involvement in the …

Chronic ethanol ingestion is known to cause oxidative damage to a number of organs
including the brain. This is partly due to the ability of ethanol to enhance oxygen free radical …

Rationale Alcoholism is a primary, chronic relapsing disease of brain reward, motivation,
memory, and related circuitry. It is characterized by an individual's continued drinking …

There are multiple mechanisms by which alcohol can damage the develo** brain, but the
type of damage induced will depend on the amount and developmental timing of exposure …

The brain is one of the major target organs of alcohol actions. Alcohol abuse can lead to
alterations in brain structure and functions and, in some cases, to neurodegeneration …

Induction of neuroimmune genes by binge drinking increases neuronal excitability and
oxidative stress, contributing to the neurobiology of alcohol dependence and causing …

The significant increase in worldwide morbidity and mortality from non-communicable
diseases (NCDs) indicates that the efficacy of existing strategies addressing this crisis may …

Brain microvascular endothelial cells (BMVEC) connected by tight junctions (TJ) form a tight
monolayer at the blood-brain barrier (BBB). We investigated the idea that BBB dysfunction …

Inflammatory processes and cytokine expression have been implicated in the pathogenesis
of several neurodegenerative disorders. Chronic ethanol intake induces brain damage …