Mechanical force is an essential physical element that contributes to the formation and
function of life. The discovery of the evolutionarily conserved PIEZO family, including PIEZO1 …

The cardiovascular system provides blood supply throughout the body and as such is
perpetually applying mechanical forces to cells and tissues. Thus, this system is primed with …

In this study, we used cryoelectron microscopy to determine the structures of the Flotillin
protein complex, part of the Stomatin, Prohibitin, Flotillin, and HflK/C (SPFH) superfamily …

Piezo channels are critical cellular sensors of mechanical forces. Despite their large size,
ubiquitous expression, and irreplaceable roles in an ever-growing list of physiological …

Our aim is to present an updated overview of the erythrocyte metabolism highlighting its
richness and complexity. We have manually collected and connected the available …

Piezo1 is a bona fide mechanosensitive ion channel ubiquitously expressed in mammalian
cells. The distribution of Piezo1 within a cell is essential for various biological processes …

The microgeometry of the cellular microenvironment profoundly impacts cellular behaviors,
yet the link between it and the ubiquitously expressed mechanosensitive ion channel …

Prune belly syndrome (PBS), also known as Eagle-Barret syndrome, is a rare, multi-system
congenital myopathy primarily affecting males. Phenotypically, PBS cases manifest three …

Calcium ions mediate the volume homeostasis of human red blood cells (RBCs) in the
circulation. The mechanism by which calcium ions affect RBC hydration states always …

PIEZO1 is a mechanosensitive channel widely presented in eukaryotic organisms. Although
the PIEZO family was discovered in 2010, main questions related to the molecular structure …