Cognitive reserve (CR) represents the ability to optimize performance and functioning to
cope with brain damage or disease. CR reflects the capability to adaptively and flexibly use …

As life expectancy continues to increase worldwide, age-related dysfunction will largely
impact our societies in the future. Aging is well established to promote the deterioration of …

Background Physical activity and exercise have been suggested as effective interventions
for the prevention and management of mild cognitive impairment (MCI) and dementia, but …

Mild cognitive impairment (MCI), representing the 'transitional zone'between normal
cognition and dementia, has become a novel topic in clinical research. Although early …

Background Disease-modifying treatments for Alzheimer's disease highlight the need for
early detection of cognitive decline. However, at present, most primary care providers do not …

Introduction Alzheimer's disease and related disorders (ADRD) progressively impair
cognitive function, prompting the need for early detection to mitigate its impact. Mild …

Cognitive decline is a natural consequence of aging, but several genetic, environmental,
and psychological factors can influence its trajectories. Among the most enduring factors, the …

Background With the rapid aging of the global population, the prevalence of mild cognitive
impairment (MCI) and dementia is anticipated to surge worldwide. MCI serves as an …

Abstract The Bio-Hermes Study was a cross-sectional observational study designed to
develop a database of blood-based and digital biomarkers to improve detection of …

The increasing burden of Alzheimer's disease (AD) emphasizes the need for effective
diagnostic and therapeutic strategies. Despite available treatments targeting amyloid beta …