Single-cell sequencing of develo** human gut reveals transcriptional links to childhood Crohn's disease
Human gut development requires the orchestrated interaction of differentiating cell types.
Here, we generate an in-depth single-cell map of the develo** human intestine at 6–10 …
Here, we generate an in-depth single-cell map of the develo** human intestine at 6–10 …
Hedgehog signaling in intestinal development and homeostasis
The hedgehog (Hh) signaling pathway plays several diverse regulatory and patterning roles
during organogenesis of the intestine and in the regulation of adult intestinal homeostasis. In …
during organogenesis of the intestine and in the regulation of adult intestinal homeostasis. In …
Distinct populations of crypt-associated fibroblasts act as signaling hubs to control colon homeostasis
MD Brügger, T Valenta, H Fazilaty, G Hausmann… - PLoS …, 2020 - journals.plos.org
Despite recent progress in recognizing the importance of mesenchymal cells for the
homeostasis of the intestinal system, the current picture of how these cells communicate with …
homeostasis of the intestinal system, the current picture of how these cells communicate with …
A bioengineering perspective on modelling the intestinal epithelial physiology in vitro
The small intestine is a specialised organ, essential for nutrient digestion and absorption. It
is lined with a complex epithelial cell layer. Intestinal epithelial cells can be cultured in three …
is lined with a complex epithelial cell layer. Intestinal epithelial cells can be cultured in three …
Differentiation of human intestinal organoids with endogenous vascular endothelial cells
Human pluripotent stem cell (hPSC)-derived intestinal organoids (HIOs) lack some cellular
populations found in the native organ, including vasculature. Using single-cell RNA …
populations found in the native organ, including vasculature. Using single-cell RNA …
Dysregulation of the NRG1/ERBB pathway causes a developmental disorder with gastrointestinal dysmotility in humans
TL Le, L Galmiche, J Levy… - The Journal of …, 2021 - Am Soc Clin Investig
Hirschsprung disease (HSCR) is the most frequent developmental anomaly of the enteric
nervous system, with an incidence of 1 in 5000 live births. Chronic intestinal pseudo …
nervous system, with an incidence of 1 in 5000 live births. Chronic intestinal pseudo …
4D materials with photoadaptable properties instruct and enhance intestinal organoid development
Intestinal organoids are self-organized tissue constructs, grown in vitro, that resemble the
structure and function of the intestine and are often considered promising as a prospective …
structure and function of the intestine and are often considered promising as a prospective …
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage
M Martín-Alonso, S Iqbal, PM Vornewald… - Nature …, 2021 - nature.com
Smooth muscle is an essential component of the intestine, both to maintain its structure and
produce peristaltic and segmentation movements. However, very little is known about other …
produce peristaltic and segmentation movements. However, very little is known about other …
Mesenchymal niches for digestive organ development, homeostasis, and disease
Mesenchymal–epithelial crosstalk plays a crucial role in organ development and stem cell
function. However, the identity of the mesenchymal cells involved in this exchange was …
function. However, the identity of the mesenchymal cells involved in this exchange was …
Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model
The establishment of the small intestinal (SI) lineage during human embryogenesis ensures
functional integrity of the intestine after birth. The chromatin dynamics that drive SI lineage …
functional integrity of the intestine after birth. The chromatin dynamics that drive SI lineage …