The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …

Cocrystals are an emerging class of crystalline materials composed of two or more different
molecules in the same crystal lattice that are physically connected by non-ionic and non …

The pharmacokinetics profile of active pharmaceutical ingredients (APIs) in the solid
pharmaceutical dosage forms is largely dependent on the solid-state characteristics of the …

The ΔpKa rule is commonly applied by chemists and crystal engineers as a guideline for the
rational design of molecular salts and co-crystals. For multi-component crystals containing …

Recently, pharmaceutical cocrystals have gained immense interest because of their
potential to tune mechanical, pharmacokinetic, and physicochemical properties of active …

Nicotine, as a major component of cigarette smoke and second-hand smoke (SHS), is highly
harmful to human health because of its carcinogenic potential. Hence, detecting it in indoor …

There is a great interest to develop co-amorphous drug delivery systems to enhance the
solubility of biopharmaceutics classification system (BCS) class II and IV drugs. However …

The prediction of cocrystal or molecular salt formation from organic acid and base
constituents in solution usually relies on the pK a rule, an empirical protocol based on the …

To improve the solubility and dissolution rate of the BCS class II drug ketoconazole, five
novel solid forms in 1: 1 stoichiometry were obtained upon liquid-assisted grinding, slurry …