The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been
widely demonstrated that neuroinflammation plays a critical role in the development of …

Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological
deficit and social and financial burdens. It is currently being managed symptomatically, with …

Spinal cord injury (SCI) is a devastating event that results in significant physical disabilities
for affected individuals. Apart from local injury within the spinal cord, SCI patients develop a …

Microglia are important mediators of neuroinflammation, which underlies neuropathic pain.
However, the molecular checkpoints controlling microglial reactivity are not well-understood …

Pain is a major and common symptom reported as a top priority in patients with rheumatoid
arthritis (RA). Intuitively, RA-related pain is often considered to be a natural consequence of …

Background Neuropathic pain is a challenging condition often refractory to existing
therapies. An increasing number of studies have indicated that the immune system plays a …

We evaluated the effects of the non-psychoactive cannabinoid cannabidiol (CBD) on the
inflammatory response and recovery of function following spinal cord injury (SCI). Female …

Spinal cord injury (SCI) is globally considered as one of the most debilitating disorders,
which interferes with daily activities and life of the affected patients. Despite many …

The microtubule-stabilizing agent paclitaxel frequently leads to chemotherapy-induced
peripheral neuropathy (CIN), which further increases the burden of disease and often …