Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Over the past decade the number and variety of protein post-translational modifications that
have been detected and characterized in bacteria have rapidly increased. Most post …

The EcoCyc model-organism database collects and summarizes experimental data for
Escherichia coli K-12. EcoCyc is regularly updated by the manual curation of individual …

Numerous biological processes are concurrently and coordinately active in every living cell.
Each of them encompasses synthetic, catalytic and regulatory functions that are, almost …

Lysine lactylation (Kla) has recently been reported to participate in regulating transcription in
human cells. However, the characterization, regulatory mechanism and functional …

Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …

Measuring precise concentrations of proteins can provide insights into biological processes.
Here we use efficient protein extraction and sample fractionation, as well as state-of-the-art …

Lysine acetylation is a conserved protein post-translational modification that links acetyl-
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …

Metabolic reprogramming is an important feature of cancers that has been closely linked to
post-translational protein modification (PTM). Lysine succinylation is a recently identified …

During aerobic growth on glucose, Escherichia coli excretes acetate, a mechanism called
“overflow metabolism.” At high concentrations, the secreted acetate inhibits growth. Several …