In recent decades, the development of targeted drugs has featured prominently in the
treatment of cancer, which is among the major causes of mortality globally. Triazole-fused …

PAX5, a member of the Paired Box (PAX) transcription factor family, is an essential factor for
B-lineage identity during lymphoid differentiation. Mechanistically, PAX5 controls gene …

Thyroid hormone receptor α1 (TRα1) mediates the genomic actions of thyroid hormone (T3).
The biology of TRα1 in growth and development has been well studied, but the functional …

Nonsense and missense mutations in the transcription factor PAX6 cause a wide range of
eye development defects, including aniridia, microphthalmia and coloboma. To understand …

Transcription factors play multifaceted roles in embryonic development and diseases. PAX1,
a paired-box transcription factor, has been elucidated to play key roles in multiple tissues …

Simple Summary The understanding of coat color genetics in the domestic horse has
advanced largely in the last few years. Specifically, many alleles influencing equine white …

The incidences of short-term or long-term adverse maternal and fetal outcomes caused by
maternal diabetes are increasing. Due to toxicity or side effects, economic pressures, and …

Paired box 4 (Pax4) is a key transcription factor involved in the embryonic development of
the pancreatic islets of Langerhans. Consisting of a conserved paired box domain and a …

Guanidinoacetic acid is the direct precursor of creatine and its phosphorylated derivative
phosphocreatine in the body. It is a safe nutritional supplement that can be used to promote …

Normal processes of embryonic development and abnormal transformation to cancer have
many parallels, and in fact many aberrant cancer cell capabilities are embryonic traits …