Human longevity is a complex trait, and to disentangle its basis has a great theoretical and
practical consequences for biomedicine. The genetics of human longevity is still poorly …

In the study of longevity, increasing importance is being placed on the concept of healthy
aging rather than considering the total number of years lived. Although the concept of …

Background The current epidemic of obesity and associated diseases calls for swift actions
to better understand the mechanisms by which genetics and environmental factors affect …

Supercentenarians (110 years or older) are the world's oldest people. Seventy four are alive
worldwide, with twenty two in the United States. We performed whole-genome sequencing …

Psychiatric disorders such as schizophrenia and bipolar disorder are caused by complex
gene–environment interactions. While recent advances in genomic technologies have …

Background DNA methylation arrays are widely used in epigenome-wide association
studies and methylation quantitative trait locus (mQTL) studies. Here, we performed the first …

Human ageing is an extremely personal process leading across the life course of individuals
to large population heterogeneity in the decline of functional capacity, health and lifespan …

DNA methylation is one of the most extensively studied epigenetic marks in humans. Yet, it
is largely unknown what causes variation in DNA methylation between individuals. The …

Background Recent state-of-the-art sequencing technologies enable the investigation of
challenging regions in the human genome and expand the scope of variant benchmarking …

Monozygotic (MZ) twins are theoretically genetically identical. Although they are revealed to
accumulate mutations after the zygote splits, discriminating between twin genomes remains …