In humans, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is highly
infective, often causes severe acute and/or long-term illness, and elicits a high rate of …

Torpor and hibernation are powerful strategies enabling animals to survive periods of low
resource availability. The state of torpor results from an active and drastic reduction of an …

Many mammals risk damage from oxidative stress stemming from frequent dives (ie, cycles
of ischemia/reperfusion and hypoxia/reoxygenation), high altitude and subterranean …

Fasting is a component of many species' life history due to environmental factors or
behavioral patterns that limit access to food. Despite metabolic and physiological challenges …

The cytoprotective transcriptor factor nuclear factor erythroid 2–related factor 2 (NRF2) is
part of a complex regulatory network that responds to environmental cues. To better …

There are over 8 million species in this world that live in widely varying environments, from
hot thermal fissures to cold arctic settings. These species have evolved over millions of …

Mammalian hibernators experience repeated hypoxic ischaemia and reperfusion during the
torpor–arousal cycle. We investigated levels of oxidative stress, antioxidant capacity, and the …

Oxidative stress is thought to be one of the main causes of ageing as it progressively
damages cell components throughout life, eventually causing cellular failure and apoptosis …

Contrasting with several theories of ageing, bats are mammals with remarkable longevity
despite their high metabolic rate, living on average three times more than other mammals of …

Alzheimer's disease (AD) poses a major worldwide health challenge because of its profound
impact on cognitive abilities and overall well-being. Despite extensive research and …