Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning
SA Langhans - Frontiers in pharmacology, 2018 - frontiersin.org
Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …
from target identification to lead discovery and optimization, preclinical validation and …
Screening out irrelevant cell-based models of disease
The common and persistent failures to translate promising preclinical drug candidates into
clinical success highlight the limited effectiveness of disease models currently used in drug …
clinical success highlight the limited effectiveness of disease models currently used in drug …
[HTML][HTML] In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models
SY Lee, IS Koo, HJ Hwang, DW Lee - SLAS Discovery, 2023 - Elsevier
Abstract Three-dimensional (3D) cell culture technology has been steadily studied since the
1990's due to its superior biocompatibility compared to the conventional two-dimensional …
1990's due to its superior biocompatibility compared to the conventional two-dimensional …
Biomaterials for three-dimensional cell culture: From applications in oncology to nanotechnology
Three-dimensional cell culture has revolutionized cellular biology research and opened the
door to novel discoveries in terms of cellular behavior and response to microenvironment …
door to novel discoveries in terms of cellular behavior and response to microenvironment …
Concerns, challenges and promises of high-content analysis of 3D cellular models
© 2018 Mac millan Publishers Li mited, part of Springer Nature. All rights reserved. deeper
penetration of light into tissue, but many areas require improvement, especially if 3D …
penetration of light into tissue, but many areas require improvement, especially if 3D …
Extracellular vesicles from organoids and 3D culture systems
S Abdollahi - Biotechnology and bioengineering, 2021 - Wiley Online Library
When discovered, extracellular vesicles (EVs) such as exosomes were thought of as junk
carriers and a means by which the cell disposed of its waste material. Over the years, the …
carriers and a means by which the cell disposed of its waste material. Over the years, the …
High throughput scaffold-based 3D micro-tumor array for efficient drug screening and chemosensitivity testing
Oncology drug development is greatly hampered by inefficient drug screening using 2D
culture. Herein, we present ready-to-use micro-scaffolds in 384-well format to generate …
culture. Herein, we present ready-to-use micro-scaffolds in 384-well format to generate …
Using 3D in vitro cell culture models in anti-cancer drug discovery
SA Langhans - Expert Opinion on Drug Discovery, 2021 - Taylor & Francis
Introduction The high failure rate in drug discovery remains a costly and time-consuming
challenge. Improving the odds of success in the early steps of drug development requires …
challenge. Improving the odds of success in the early steps of drug development requires …
A 96-well microplate bioreactor platform supporting individual dual perfusion and high-throughput assessment of simple or biofabricated 3D tissue models
Traditional 2D monolayer cell cultures and submillimeter 3D tissue construct cultures used
widely in tissue engineering are limited in their ability to extrapolate experimental data to …
widely in tissue engineering are limited in their ability to extrapolate experimental data to …
Physical and biological advances in endothelial cell-based engineered co-culture model systems
CT Mierke - Seminars in Cell & Developmental Biology, 2023 - Elsevier
Scientific knowledge in the field of cell biology and mechanobiology heavily leans on cell-
based in vitro experiments and models that favor the examination and comprehension of …
based in vitro experiments and models that favor the examination and comprehension of …