Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

Gene expression in bacteria relies on promoter recognition by the DNA-dependent RNA
polymerase and subsequent transcription initiation. Bacterial cells are able to tune their …

The most common prokaryotic signal transduction mechanisms are the one-component
systems in which a single polypeptide contains both a sensory domain and a DNA-binding …

Gene expression occurs in two essential steps: transcription and translation. In bacteria, the
two processes are tightly coupled in time and space, and highly regulated. Tight regulation …

Transcription factors play an indispensable role in maintaining cellular viability and finely
regulating complex internal metabolic networks. These crucial bioactive functions rely on …

Streptomyces are Gram-positive microorganisms able to adapt and respond to different
environmental conditions. It is the largest genus of Actinobacteria comprising over 900 …

Introduction In plants, leaves and flowers originate from the shoot apical meristem. In an
indeterminate shoot apical meristem, stem cells persist for the life of the plant. In a …

The posttranslational modification of proteins and their regulation by metabolites represent
conserved mechanisms in biology. At the confluence of these two processes, we report that …

Biological regulation ubiquitously depends on protein allostery, but the regulatory
mechanisms are incompletely understood, especially in proteins that undergo ligand …

Proteins are tiny models of biological complexity: specific interactions among their many
amino acids cause proteins to fold into elaborate structures, assemble with other proteins …