Dynamic retinal vessel analysis: flickering a light into the brain

A Peterfi, ACC Pinaffi-Langley, Z Szarvas… - Frontiers in Aging …, 2025 - frontiersin.org
Introduction Growing aging populations pose new challenges to public health as the number
of people living with dementia grows in tandem. To alleviate the burden of dementia …

Modal Analysis of Cerebrovascular Effects for Digital Health Integration of Neurostimulation Therapies—A Review of Technology Concepts

M Stefanski, Y Arora, M Cheung, A Dutta - Brain Sciences, 2024 - mdpi.com
Transcranial electrical stimulation (tES) is increasingly recognized for its potential to mod-
ulate cerebral blood flow (CBF) and evoke cerebrovascular reactivity (CVR), which are …

Neurovascular coupling, functional connectivity, and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment

CD Owens, CB Pinto, P Mukli, R Gulej… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Mild cognitive impairment (MCI) is a prodromal stage of dementia.
Understanding the mechanistic changes from healthy aging to MCI is critical for …

Time-restricted eating for prevention of age-related vascular cognitive decline in older adults: A protocol for a single-arm open-label interventional trial

AC da C. Pinaffi-Langley, Z Szarvas, A Peterfi… - PloS one, 2024 - journals.plos.org
Age-related cerebromicrovascular endothelial dysfunction underlies the initiation and
progression of cognitive dysfunction and dementia, thus increasing the susceptibility of older …

[HTML][HTML] COVID-19 Exacerbates Neurovascular Uncoupling and Contributes to Endothelial Dysfunction in Patients with Mild Cognitive Impairment

CD Owens, CB Pinto, Z Szarvas, M Muranyi… - Biomolecules, 2024 - mdpi.com
Mild cognitive impairment (MCI) affects nearly 20% of older adults worldwide, with no
targetable interventions for prevention. COVID-19 adversely affects cognition, with> 70% of …

Neurovascular coupling impairment as a mechanism for cognitive deficits in COVID-19

CD Owens, C Bonin Pinto, S Detwiler… - Brain …, 2024 - academic.oup.com
Components that comprise our brain parenchymal and cerebrovascular structures provide a
homeostatic environment for proper neuronal function to ensure normal cognition. Cerebral …

Prenatal exposure to low doses of benzophenone-3 elicits disruption of cortical vasculature in fetuses through perturbations in Wnt/β-catenin signaling correlating with …

Y Luo, Y Zhang, Y Feng, X Zeng, D Zhu, Y Yang, H Hu… - Toxicology, 2024 - Elsevier
Abstract Benzophenone-3 (BP-3), commonly used in personal care products, is routinely
detected in environmental and human matrices. Evidence delineates a correlation between …

Photobiomodulation in the aging brain: a systematic review from animal models to humans

L Rodríguez-Fernández, C Zorzo, JL Arias - GeroScience, 2024 - Springer
Aging is a multifactorial biological process that may be associated with cognitive decline.
Photobiomodulation (PBM) is a non-pharmacological therapy that shows promising results …

Energy metabolism dysregulation, cerebrovascular aging, and time-restricted eating: Current evidence and proof-of-concept findings

AC da C Pinaffi-Langley, CB Pinto, P Mukli… - PNAS …, 2024 - academic.oup.com
Dysregulated energy metabolism is a hallmark of aging, including brain aging; thus,
strategies to restore normal metabolic regulation are at the forefront of aging research …

Influence of individual's age on the characteristics of brain effective connectivity

N Nourzadegan, S Baghernezhad, MR Daliri - GeroScience, 2024 - Springer
Given the increasing number of older adults in society, there is a growing need for studies
on changes in the aging brain. The aim of this research is to investigate the effective …