Axon degeneration is a prominent early feature of most neurodegenerative disorders and
can also be induced directly by nerve injury in a process known as Wallerian degeneration …

Nicotinamide adenine dinucleotide (NAD) is an important co-factor involved in numerous
physiological processes, including metabolism, post-translational protein modification, and …

The genome of pancreatic ductal adenocarcinoma (PDAC) frequently contains deletions of
tumour suppressor gene loci, most notably SMAD4, which is homozygously deleted in …

Summary SARM1 is an NAD (P) glycohydrolase and TLR adapter with an essential,
prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD …

The numerous biological roles of NAD+ are organized and coordinated via its
compartmentalization within cells. The spatial and temporal partitioning of this intermediary …

Peripheral nerves regenerate following injury due to the effective activation of the intrinsic
growth capacity of the neurons and the formation of a permissive pathway for outgrowth due …

Axon loss underlies symptom onset and progression in many neurodegenerative disorders.
Axon degeneration in injury and disease is promoted by activation of the NAD-consuming …

NAD plays essential redox and non-redox roles in cell biology. In mammals, its de novo and
recycling biosynthetic pathways encompass two independent branches, the “amidated” and …

Trachyspermum ammi (Apiaceae) is a plant with a good reputation in the traditional Persian
and Ayurvedic medicine. The hydrodistilled essential oil from the fruits of T. ammi, known as …

NMNAT2 is an NAD+-synthesizing enzyme with an essential axon maintenance role in
primary culture neurons. We have generated an Nmnat2 gene trap mouse to examine the …