Microtubules, formed by α-and β-tubulin heterodimer, are considered as a major target to
prevent the proliferation of tumor cells. Microtubule-targeted agents have become …

Isochromans are well recognized heterocyclic compounds in drug discovery which produce
diverse therapeutically related applications in pharmacological practices. Medicinal …

A series of novel quinoline–chalcone derivatives were designed, synthesized, and
evaluated for their antiproliferative activity. Among them, compound 24d exhibited the most …

Acetylene gas is an important feedstock for chemical production, although it is underutilized
in organic synthesis. We have developed an intermolecular gold (I)-catalyzed alkyne/alkene …

A series of novel isocombretastatin A-4 (isoCA-4) analogs were designed and synthesized
by replacing 3, 4, 5-trimethoylphenyl and isovanillin of isoCA-4 with quinoline and indole …

Most vascular disrupting agents (VDAs) fail to prevent the regrowth of blood vessels at the
edge of tumors, causing tumor rebound and relapse. Herein, a series of novel …

Further optimization of the trimethoxyphenyl scaffold of parent chalcone compound (2a) by
introducing a pyridine ring afforded a series of novel pyridine-chalcone derivatives as …

Angiogenesis plays an important role in tumour generation and progression, which is used
to supply nutrients and metastasis. Herein, a series of novel dihydro-1 H-indene derivatives …

Twenty-two novel indole-vinyl sulfone derivatives were designed, synthesized and
evaluated as tubulin polymerization inhibitors. The physicochemical and drug-likeness …

ATP-binding cassette subfamily G and tubulin pharmacological mechanisms decrease the
effectiveness of anticancer drugs by modulating drug absorption and by creating tubulin …