How inhaled corticosteroids target inflammation in COPD
Inhaled corticosteroids (ICS) are the most commonly used anti-inflammatory drugs for the
treatment of COPD. COPD has been previously described as a “corticosteroid-resistant” …
treatment of COPD. COPD has been previously described as a “corticosteroid-resistant” …
Lipid metabolism in chronic obstructive pulmonary disease
H Chen, Z Li, L Dong, Y Wu, H Shen… - International journal of …, 2019 - Taylor & Francis
Dysregulated lipid metabolism plays crucial roles in various diseases, including diabetes
mellitus, cancer, and neurodegeneration. Recent studies suggest that alterations in major …
mellitus, cancer, and neurodegeneration. Recent studies suggest that alterations in major …
Regulation of ATP binding cassette transporter A1 (ABCA1) expression: cholesterol-dependent and–independent signaling pathways with relevance to inflammatory …
P He, IC Gelissen, AJ Ammit - Respiratory research, 2020 - Springer
The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid
homeostasis in cardiovascular disease is well established. More recently, the important …
homeostasis in cardiovascular disease is well established. More recently, the important …
Lipid metabolism disorders in the comorbid course of nonalcoholic fatty liver disease and chronic obstructive pulmonary disease
S Kotlyarov, A Bulgakov - Cells, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is currently among the most common liver
diseases. Unfavorable data on the epidemiology of metabolic syndrome and obesity have …
diseases. Unfavorable data on the epidemiology of metabolic syndrome and obesity have …
The nuclear receptor LXR modulates interleukin-18 levels in macrophages through multiple mechanisms
IL-18 is a member of the IL-1 family involved in innate immunity and inflammation.
Deregulated levels of IL-18 are involved in the pathogenesis of multiple disorders including …
Deregulated levels of IL-18 are involved in the pathogenesis of multiple disorders including …
Ablation of Liver X receptors α and β leads to spontaneous peripheral squamous cell lung cancer in mice
The etiology of peripheral squamous cell lung cancer (PSCCa) remains unknown. Here, we
show that this condition spontaneously develops in mice in which the genes for two …
show that this condition spontaneously develops in mice in which the genes for two …
The effects of corticosteroids on COPD lung macrophages: a pooled analysis
Background There is large variation in the therapeutic response to inhaled corticosteroids
(ICS) in COPD patients. We present a pooled analysis of our previous studies investigating …
(ICS) in COPD patients. We present a pooled analysis of our previous studies investigating …
A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation
D Morichika, N Miyahara, U Fujii, A Taniguchi… - Respiratory …, 2019 - Springer
Abstract Background Retinoid X receptors (RXRs) are members of the nuclear receptor (NR)
superfamily that mediate signalling by 9-cis retinoic acid, a vitamin A derivative. RXRs play …
superfamily that mediate signalling by 9-cis retinoic acid, a vitamin A derivative. RXRs play …
The oxysterome and its receptors as pharmacological targets in inflammatory diseases
Oxysterols have gained attention over the last decades and are now considered as fully
fledged bioactive lipids. The study of their levels in several conditions, including …
fledged bioactive lipids. The study of their levels in several conditions, including …
Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients
T Southworth, J Plumb, V Gupta, J Pearson, I Ramis… - Respiratory …, 2016 - Springer
Background Phosphatidylinositol 3-kinase delta (PI3Kδ) and Janus-activated kinases (JAK)
are both novel anti-inflammatory targets in asthma that affect lymphocyte activation. We have …
are both novel anti-inflammatory targets in asthma that affect lymphocyte activation. We have …