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Valid inference for machine learning-assisted genome-wide association studies
Abstract Machine learning (ML) has become increasingly popular in almost all scientific
disciplines, including human genetics. Owing to challenges related to sample collection and …
disciplines, including human genetics. Owing to challenges related to sample collection and …
Nr4a1 enhances Wnt4 transcription to promote mesenchymal stem cell osteogenesis and alleviates inflammation-inhibited bone regeneration
Intense inflammatory response impairs bone marrow mesenchymal stem cell (BMSC)-
mediated bone regeneration, with transforming growth factor (TGF)-β1 being the most highly …
mediated bone regeneration, with transforming growth factor (TGF)-β1 being the most highly …
[HTML][HTML] Bone and Entheseal Targets for Growth Factors in Diffuse Idiopathic Skeletal Hyperostosis
GO Littlejohn - Seminars in Arthritis and Rheumatism, 2024 - Elsevier
Introduction Diffuse idiopathic skeletal hyperostosis (DISH) is a common condition of the
adult skeleton where new bone growth occurs in entheseal and bony regions. The cause for …
adult skeleton where new bone growth occurs in entheseal and bony regions. The cause for …
Spatiotemporal changes in imaging features associated with diffuse idiopathic skeletal hyperostosis (DISH)
Objectives The purpose of our study was to characterise spatiotemporal features of disease
progression in people with diffuse idiopathic skeletal hyperostosis (DISH), early-phase …
progression in people with diffuse idiopathic skeletal hyperostosis (DISH), early-phase …
[HTML][HTML] Osteophyte bridge formation correlates with vascular calcification and cardiovascular disease in diffuse idiopathic skeletal hyperostosis
R Hirota, A Teramoto, M Yoshimoto… - Journal of Clinical …, 2023 - mdpi.com
Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory spondyloarthropathy
characterized by ectopic calcification of spinal cord tissue. Its etiology is possibly polygenic …
characterized by ectopic calcification of spinal cord tissue. Its etiology is possibly polygenic …
Functional Injectable Hydrogel for Bone Regeneration: Regulation of the circSRPK1/miR‐320a Axis and Targeting Multiple Osteogenic Pathways via CDH2 and …
Y Wang, X Mao, D Li, Y Zhao, X Yang, Z Zheng… - …, 2025 - Wiley Online Library
Hydrogels loaded with microRNA (miRNA) have shown promise in bone‐defect repair.
Here, we present the first report of miRNA‐loaded hydrogels containing bioactivities to treat …
Here, we present the first report of miRNA‐loaded hydrogels containing bioactivities to treat …
Association between serum interleukin-17 levels and ectopic bone formation in OPLL patients with DISH
Z He, NTC Tung, Y Yahara, H Makino, T Yasuda… - …, 2024 - academic.oup.com
Objective To investigate the relationship between the severity and morphology of
heterotopic ossification in the spinal ligaments including sacroiliac (SI) joints, and serum …
heterotopic ossification in the spinal ligaments including sacroiliac (SI) joints, and serum …
Intervertebral Disc Degeneration Mediates the Causal Effect of Genetically Predicted Diffuse Idiopathic Skeletal Hyperostosis on Spinal Stenosis: Evidence From a …
Y Shen, Y Jiang, R Jiang, Y Huang, S Zhan… - JOR …, 2025 - Wiley Online Library
Background Previous studies have noted an association between diffuse idiopathic skeletal
hyperostosis (DISH) and spinal stenosis (SS), although causation is unclear. This study …
hyperostosis (DISH) and spinal stenosis (SS), although causation is unclear. This study …
Prevalence and characteristics of osseous bridging between vertebral bodies in the cervical spine: A skeletal study
Osseous bridging (OB) in three or more segments of motions (SOMs) of the mobile spine
was initially defined as diffuse idiopathic skeletal hyperostosis (DISH), located particularly in …
was initially defined as diffuse idiopathic skeletal hyperostosis (DISH), located particularly in …
Valid inference for machine learning-assisted GWAS
Abstract Machine learning (ML) has revolutionized analytical strategies in almost all
scientific disciplines including human genetics and genomics. Due to challenges in sample …
scientific disciplines including human genetics and genomics. Due to challenges in sample …