Valid inference for machine learning-assisted genome-wide association studies

J Miao, Y Wu, Z Sun, X Miao, T Lu, J Zhao, Q Lu - Nature genetics, 2024 - nature.com
Abstract Machine learning (ML) has become increasingly popular in almost all scientific
disciplines, including human genetics. Owing to challenges related to sample collection and …

Nr4a1 enhances Wnt4 transcription to promote mesenchymal stem cell osteogenesis and alleviates inflammation-inhibited bone regeneration

Y Gao, Y Zou, D Sokolowskei, X **ng, RJ Tower, Z Lai… - Molecular Therapy, 2024 - cell.com
Intense inflammatory response impairs bone marrow mesenchymal stem cell (BMSC)-
mediated bone regeneration, with transforming growth factor (TGF)-β1 being the most highly …

[HTML][HTML] Bone and Entheseal Targets for Growth Factors in Diffuse Idiopathic Skeletal Hyperostosis

GO Littlejohn - Seminars in Arthritis and Rheumatism, 2024 - Elsevier
Introduction Diffuse idiopathic skeletal hyperostosis (DISH) is a common condition of the
adult skeleton where new bone growth occurs in entheseal and bony regions. The cause for …

Spatiotemporal changes in imaging features associated with diffuse idiopathic skeletal hyperostosis (DISH)

DE Fournier, MC Battie, CA Séguin - RMD open, 2024 - rmdopen.bmj.com
Objectives The purpose of our study was to characterise spatiotemporal features of disease
progression in people with diffuse idiopathic skeletal hyperostosis (DISH), early-phase …

[HTML][HTML] Osteophyte bridge formation correlates with vascular calcification and cardiovascular disease in diffuse idiopathic skeletal hyperostosis

R Hirota, A Teramoto, M Yoshimoto… - Journal of Clinical …, 2023 - mdpi.com
Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory spondyloarthropathy
characterized by ectopic calcification of spinal cord tissue. Its etiology is possibly polygenic …

Functional Injectable Hydrogel for Bone Regeneration: Regulation of the circSRPK1/miR‐320a Axis and Targeting Multiple Osteogenic Pathways via CDH2 and …

Y Wang, X Mao, D Li, Y Zhao, X Yang, Z Zheng… - …, 2025 - Wiley Online Library
Hydrogels loaded with microRNA (miRNA) have shown promise in bone‐defect repair.
Here, we present the first report of miRNA‐loaded hydrogels containing bioactivities to treat …

Association between serum interleukin-17 levels and ectopic bone formation in OPLL patients with DISH

Z He, NTC Tung, Y Yahara, H Makino, T Yasuda… - …, 2024 - academic.oup.com
Objective To investigate the relationship between the severity and morphology of
heterotopic ossification in the spinal ligaments including sacroiliac (SI) joints, and serum …

Intervertebral Disc Degeneration Mediates the Causal Effect of Genetically Predicted Diffuse Idiopathic Skeletal Hyperostosis on Spinal Stenosis: Evidence From a …

Y Shen, Y Jiang, R Jiang, Y Huang, S Zhan… - JOR …, 2025 - Wiley Online Library
Background Previous studies have noted an association between diffuse idiopathic skeletal
hyperostosis (DISH) and spinal stenosis (SS), although causation is unclear. This study …

Prevalence and characteristics of osseous bridging between vertebral bodies in the cervical spine: A skeletal study

D Ezra, R Mader, A Yosef, L Kalichman… - Clinical …, 2025 - Wiley Online Library
Osseous bridging (OB) in three or more segments of motions (SOMs) of the mobile spine
was initially defined as diffuse idiopathic skeletal hyperostosis (DISH), located particularly in …

Valid inference for machine learning-assisted GWAS

J Miao, Y Wu, Z Sun, X Miao, T Lu, J Zhao, Q Lu - medRxiv, 2024 - medrxiv.org
Abstract Machine learning (ML) has revolutionized analytical strategies in almost all
scientific disciplines including human genetics and genomics. Due to challenges in sample …