[HTML][HTML] Regulation mechanism of endoplasmic reticulum stress on metabolic enzymes in liver diseases
S Zhou, K Cheng, Y Peng, Y Liu, Q Hu, S Zeng… - Pharmacological …, 2024 - Elsevier
The endoplasmic reticulum (ER) plays a pivotal role in protein folding and secretion, Ca 2+
storage, and lipid synthesis in eukaryotic cells. When the burden of protein synthesis and …
storage, and lipid synthesis in eukaryotic cells. When the burden of protein synthesis and …
Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
S Ruf, S Rajagopal, SV Kadnur, MS Hallur, S Rani… - Scientific Reports, 2022 - nature.com
Nicotinamide N-methyltransferase (NNMT) is a metabolic regulator that catalyzes the
methylation of nicotinamide (Nam) using the co-factor S-adenosyl-L-methionine to form 1 …
methylation of nicotinamide (Nam) using the co-factor S-adenosyl-L-methionine to form 1 …
Structure–Activity Relationship Studies on Cell-Potent Nicotinamide N-Methyltransferase Bisubstrate Inhibitors
Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme implicated in multiple
diseases, making it a promising therapeutic target. Building upon our recently reported …
diseases, making it a promising therapeutic target. Building upon our recently reported …
[HTML][HTML] Nicotinamide N-methyltransferase and liver diseases
G Liang, Y Li, Y Lin, X Yang, J Yang, S Hu, A Liu - Genes & Diseases, 2023 - Elsevier
Cellular metabolism-induced epigenetic regulation is essential for the maintenance of
cellular homeostasis. Nicotinamide N-methyltransferase (NNMT) is emerging as a key point …
cellular homeostasis. Nicotinamide N-methyltransferase (NNMT) is emerging as a key point …
Control of NAD+ homeostasis by autophagic flux modulates mitochondrial and cardiac function
Impaired autophagy is known to cause mitochondrial dysfunction and heart failure, in part
due to altered mitophagy and protein quality control. However, whether additional …
due to altered mitophagy and protein quality control. However, whether additional …
Exploring Unconventional SAM Analogues To Build Cell‐Potent Bisubstrate Inhibitors for Nicotinamide N‐Methyltransferase
Nicotinamide N‐methyltransferase (NNMT) methylates nicotinamide and has been
associated with various diseases. Herein, we report the first cell‐potent NNMT bisubstrate …
associated with various diseases. Herein, we report the first cell‐potent NNMT bisubstrate …
Jia-ga-song-tang protection against alcoholic liver and intestinal damage
J Fang, Y Wu, C Gan, S Ruan, X He, B Wang… - Frontiers in …, 2022 - frontiersin.org
Gut-liver axis and cellular homeostasis play key roles in alcohol liver disease (ALD). Nuclear
factor (erythroid-derived 2)-like 2 (Nrf2) is a stress-sensitive guarantor of cellular …
factor (erythroid-derived 2)-like 2 (Nrf2) is a stress-sensitive guarantor of cellular …
ATF4-mediated CD36 upregulation contributes to palmitate-induced lipotoxicity in hepatocytes
Hepatic lipotoxicity plays a central role in the pathogenesis of nonalcoholic fatty liver
disease; however, the underlying mechanisms remain elusive. Here, using both cultured …
disease; however, the underlying mechanisms remain elusive. Here, using both cultured …
Hepatocyte-specific depletion of Nnmt protects mice from non-alcoholic steatohepatitis
NNMT is an enzyme that mediates the conversion of nicotinamide (NAM) to 1-
methylnicotinamide (MNA), while consuming a methyl group from S-Adenosyl methionine …
methylnicotinamide (MNA), while consuming a methyl group from S-Adenosyl methionine …
The storage conditions of high-fat diet are the key factors for diet-induced obesity and liver damage
The diet-induced obesity (DIO) mouse model has been widely used for obesity studies. The
effects of storage conditions on the composition of nutrients in high-fat diets (HFDs) and their …
effects of storage conditions on the composition of nutrients in high-fat diets (HFDs) and their …