The contribution of angiogenesis to the process of metastasis

DR Bielenberg, BR Zetter - The Cancer Journal, 2015 - journals.lww.com
The role of angiogenesis in tumor growth has been studied continuously for over 45 years. It
is now appreciated that angiogenesis is also essential for the dissemination and …

[HTML][HTML] Current and potential imaging applications of ferumoxytol for magnetic resonance imaging

GB Toth, CG Varallyay, A Horvath, MR Bashir… - Kidney international, 2017 - Elsevier
Contrast-enhanced magnetic resonance imaging is a commonly used diagnostic tool.
Compared with standard gadolinium-based contrast agents, ferumoxytol (Feraheme, AMAG …

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

J Kloepper, L Riedemann… - Proceedings of the …, 2016 - National Acad Sciences
Inhibition of the vascular endothelial growth factor (VEGF) pathway has failed to improve
overall survival of patients with glioblastoma (GBM). We previously showed that angiopoietin …

An Ultrahigh‐Field‐Tailored T1T2 Dual‐Mode MRI Contrast Agent for High‐Performance Vascular Imaging

J Wang, Y Jia, Q Wang, Z Liang, G Han… - Advanced …, 2021 - Wiley Online Library
The assessment of vascular anatomy and functions using magnetic resonance imaging
(MRI) is critical for medical diagnosis, whereas the commonly used low‐field MRI system (≤ …

Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors

M Iv, N Telischak, D Feng, SJ Holdsworth… - …, 2015 - Taylor & Francis
Current neuroimaging provides detailed anatomic and functional evaluation of brain tumors,
allowing for improved diagnostic and prognostic capabilities. Some challenges persist even …

Implications of neurovascular uncoupling in functional magnetic resonance imaging (fMRI) of brain tumors

RW Pak, DH Hadjiabadi, J Senarathna… - Journal of Cerebral …, 2017 - journals.sagepub.com
Functional magnetic resonance imaging (fMRI) serves as a critical tool for presurgical
map** of eloquent cortex and changes in neurological function in patients diagnosed with …

Increased antiangiogenic effect by blocking CCL2-dependent macrophages in a rodent glioblastoma model: correlation study with dynamic susceptibility contrast …

HR Cho, N Kumari, H Thi Vu, H Kim, CK Park… - Scientific reports, 2019 - nature.com
When glioblastoma multiforme (GBM) is treated with anti-vascular endothelial growth factor
(VEGF) agents, it commonly exhibits tumor progression due to the development of …

Tumor-derived pericytes driven by EGFR mutations govern the vascular and immune microenvironment of gliomas

B Segura-Collar, M Garranzo-Asensio, B Herranz… - Cancer research, 2021 - AACR
The extraordinary plasticity of glioma cells allows them to contribute to different cellular
compartments in tumor vessels, reinforcing the vascular architecture. It was recently …

Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma

J Kalpathy-Cramer, V Chandra, X Da, Y Ou… - Journal of neuro …, 2017 - Springer
Targeting tumor angiogenesis is a potential therapeutic strategy for glioblastoma because of
its high vascularization. Tivozanib is an oral pan-VEGF receptor tyrosine kinase inhibitor that …

Tumor vessel targeted self-assemble nanoparticles for amplification and prediction of the embolization effect in hepatocellular carcinoma

Y Wang, W Shang, H Zhong, T Luo, M Niu, K Xu… - ACS …, 2020 - ACS Publications
Vessel embolization is recommended as the first line treatment for unresectable
hepatocellular carcinoma (HCC). However, owing to the imprecise vessel embolization and …