In multicellular organisms, homeostasis is maintained through a balance between cell
proliferation and cell death. Although much is known about the control of cell proliferation …

A plethora of physiological and pathological stimuli induce and activate a group of DNA
binding proteins that form AP-1 dimers. These proteins include the Jun, Fos and ATF …

A rapid and simple procedure is presented to obtain nearly pure populations of human
neuron‐like cells from the SH‐SY5Y neuroblastoma cell line. Sequential exposure of SH …

Apoptosis is a morphologically distinct form of programmed cell death that plays a major role
during development, homeostasis, and in many diseases including cancer, acquired …

In multicellular organisms, mutations in somatic cells affecting critical genes that regulate
cell proliferation and survival cause fatal cancers. Repair of the damage is one obvious …

Bile acids are a group of molecular species of acidic steroids with peculiar physical-
chemical and biological characteristics. At high concentrations they become toxic to …

The microtubule-associated protein tau, abundant in neurons, has gained notoriety due to
the fact that it is deposited in cells as fibrillar lesions in numerous neurodegenerative …

Adult CNS neurons are typically described as permanently postmitotic but there is probably
nothing permanent about the neuronal cell cycle arrest. Rather, it appears that these highly …

Chondroitin sulfate proteoglycans (CS-PGs) expressed by reactive astrocytes may
contribute to the axon growth-inhibitory environment of the injured CNS. The specific …

Elevated levels of β-Amyloid (Aβ) are present in the brains of individuals with either the
sporadic or familial form of Alzheimer's disease (AD), and the deposition of Aβ within the …